Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
| ▸ | HTR6 | P50406 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.40 |
| ▸ | MDM4 | O15151 | 1/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28503037 | 0.93 | HTR7 (0.48) | NPC1RAB9AHTR7HTR6ALDH1A1 | |
| SCHEMBL28905374 | 0.85 | NPC1 (0.46) | NPC1RAB9AHTR7HTR6ALDH1A1 | |
| SCHEMBL28500486 | 0.84 | PRKACA (0.49) | RAB9AHTR7HTR6ALDH1A1MAPT | |
| SCHEMBL28502903 | 0.81 | HTR7 (0.44) | NPC1RAB9AHTR7HTR6ALDH1A1 | |
| SCHEMBL28508740 | 0.80 | TP53 (0.52) | NPC1RAB9AHTR7HTR6ALDH1A1 | |
| SCHEMBL28506801 | 0.79 | TP53 (0.48) | NPC1RAB9AHTR7HTR6ALDH1A1 | |
| SCHEMBL28507696 | 0.79 | SMN1; SMN2 (0.48) | NPC1RAB9AHTR7HTR6ALDH1A1 | |
| SCHEMBL28507714 | 0.78 | HTR7 (0.48) | NPC1RAB9AHTR7HTR6ALDH1A1 | |
| SCHEMBL28904632 | 0.77 | MDM2 (0.60) | HTR7HTR6ALDH1A1MAPTMEN1 | |
| SCHEMBL28497886 | 0.76 | LMNA (0.40) | NPC1RAB9AHTR7HTR6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112174937-B | 3- (5-imidazolyl) indole compound and preparation method and application thereof | 南京农业大学 | 2022-06-03 | — | — | CN | disclosed |
| CN-112174937-A | 3- (5-imidazolyl) indole compound and preparation method and application thereof | 南京农业大学 | 2021-01-05 | — | — | CN | disclosed |