Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.48 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.46 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | MDM4 | O15151 | 1/20 | 0.39 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28505004 | 0.86 | SMN1; SMN2 (0.48) | SMN1; SMN2CYP11B1CYP11B2HTR7HTR6 | |
| SCHEMBL28497886 | 0.86 | LMNA (0.40) | SMN1; SMN2HTR7HTR6ALDH1A1MAPK1 | |
| SCHEMBL28496316 | 0.85 | MEN1 (0.42) | HTR7HTR6TP53MEN1KMT2A | |
| SCHEMBL28506801 | 0.84 | TP53 (0.48) | SMN1; SMN2CYP11B1CYP11B2HTR7HTR6 | |
| SCHEMBL28508740 | 0.83 | TP53 (0.52) | SMN1; SMN2CYP11B1CYP11B2HTR7HTR6 | |
| SCHEMBL28505102 | 0.81 | CYP11B1 (0.49) | SMN1; SMN2CYP11B1CYP11B2HTR7HTR6 | |
| SCHEMBL28503037 | 0.81 | HTR7 (0.48) | SMN1; SMN2HTR7HTR6ALDH1A1MAPK1 | |
| SCHEMBL28904632 | 0.80 | MDM2 (0.60) | SMN1; SMN2CYP11B1CYP11B2HTR7HTR6 | |
| SCHEMBL28502903 | 0.80 | HTR7 (0.44) | SMN1; SMN2HTR7HTR6ALDH1A1MAPK1 | |
| SCHEMBL28505050 | 0.79 | NPC1 (0.46) | SMN1; SMN2HTR7HTR6ALDH1A1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112174937-B | 3- (5-imidazolyl) indole compound and preparation method and application thereof | 南京农业大学 | 2022-06-03 | — | — | CN | disclosed |
| CN-112174937-A | 3- (5-imidazolyl) indole compound and preparation method and application thereof | 南京农业大学 | 2021-01-05 | — | — | CN | disclosed |