Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | TNK2 | Q07912 | 3/20 | 0.37 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.33 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | ACP1 | P24666 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.31 |
| ▸ | SELE | P16581 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 2/20 | 0.31 |
| ▸ | PPARA | Q07869 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11627980 | 0.73 | MEN1 (0.42) | MEN1KMT2AKDM4CICAM1SELE | |
| SCHEMBL7137362 | 0.72 | GAA (0.35) | MEN1KMT2ATNK2ITGB1ITGA4 | |
| SCHEMBL13670675 | 0.70 | MEN1 (0.51) | MEN1KMT2ALMNAMGLL | |
| SCHEMBL4776765 | 0.69 | MEN1 (0.52) | MEN1KMT2AKDM4CALDH1A1 | |
| SCHEMBL2125481 | 0.69 | KMT2A (0.37) | MEN1KMT2ATNK2ALDH1A1 | |
| SCHEMBL8874230 | 0.66 | ITGB1 (0.42) | ITGB1ITGA4GAACHRNB2CHRNB4 | |
| SCHEMBL24581535 | 0.66 | TNK2 (0.37) | MEN1KMT2ATNK2ITGB1ITGA4 | |
| SCHEMBL6210554 | 0.66 | MEN1 (0.51) | MEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL6300033 | 0.65 | MAPT (0.49) | MEN1KMT2AKDM4CGAASMN1; SMN2 | |
| SCHEMBL11632207 | 0.64 | ALDH1A1 (0.39) | MEN1KMT2AKDM4CALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3682880-A1 | TREATMENT OF HOT FLUSHES, VASOMOTOR SYMPTOMS, AND NIGHT SWEATS WITH SEX STEROID PRECURSORS IN COMBINATION WITH SELECTIVE ESTROGEN RECEPTOR MODULATORS | Endorecherche, Inc. (CA) | 2020-07-22 | — | — | EP | disclosed |
| US-10548903-B2 | Treatment of male androgen deficiency symptoms or diseases with sex steroid precursor combined with SERM | ENDORECHERCHE, INC. (CA) | 2020-02-04 | — | — | US | disclosed |
| US-20190269697-A1 | A METHOD OF TREATING AND PREVENTING LOSS OF COGNITION | ENDORECHERCHE, INC. (CA) | 2019-09-05 | — | — | US | disclosed |
| US-20190269696-A1 | METHOD OF PREVENTING ALZHEIMIER'S DISEASE | ENDORECHERCHE, INC. (CA) | 2019-09-05 | — | — | US | disclosed |
| US-10342805-B2 | Treatment of Alzheimer's disease, loss of cognition, memory loss and dementia with sex steroid precursors in combination with selective estrogen receptor modulators | ENDORECHERCHE, INC. (CA) | 2019-07-09 | — | — | US | disclosed |
| US-20170290847-A1 | TREATMENT OF MALE ANDROGEN DEFICIENCY SYMPTOMS OR DISEASES WITH SEX STEROID PRECURSOR COMBINED WITH SERM | ENDORECHERCHE, INC. | 2017-10-12 | — | — | US | disclosed |
| US-9744177-B2 | Treatment of male androgen deficiency symptoms or diseases with sex steroid precursor combined with SERM | ENDORECHERCHE, INC. (CA) | 2017-08-29 | — | — | US | disclosed |
| EP-3178480-A1 | TREATMENT OF HOT FLUSHES, VASOMOTOR SYMPTOMS, AND NIGHT SWEATS WITH SEX STEROID PRECURSORS IN COMBINATION WITH SELECTIVE ESTROGEN RECEPTOR MODULATORS | Endorecherche, Inc. (CA) | 2017-06-14 | — | — | EP | disclosed |
| EP-3116510-A1 | TREATMENT OF MALE ANDROGEN DEFICIENCY SYMPTOMS OR DISEASES WITH SEX STEROID PRECURSOR COMBINED WITH SERM | Endorecherche, Inc. (CA) | 2017-01-18 | — | — | EP | disclosed |
| WO-2015135061-A1 | TREATMENT OF MALE ANDROGEN DEFICIENCY SYMPTOMS OR DISEASES WITH SEX STEROID PRECURSOR COMBINED WITH SERM | ENDORECHERCHE, INC. (CA) | 2015-09-17 | — | — | WO | disclosed |
| US-20040034000-A1 | Methods of treating and/or suppressing insulin resistance | ENDORECHERCHE, INC. | 2004-02-19 | — | — | US | disclosed |
| US-6670346-B1 | Treatment and/or inhibition of the development of osteoporosis, breast cancer, hypercholesterolemia, hyperlipidemia or atherosclerosis in susceptible warm-blooded animals including humans, administering selective estrogen | ENDORECHERCHE, INC. (CA) | 2003-12-30 | — | — | US | disclosed |
| US-20030065008-A1 | Selective estrogen receptor modulators in combination with estrogens | ENDORECHERCHE, INC. | 2003-04-03 | — | — | US | disclosed |
| US-20030040510-A1 | Selective estrogen receptor modulators in combination with estrogens | ENDORECHERCHE, INC. | 2003-02-27 | — | — | US | disclosed |
| US-20020198179-A1 | Selective estrogen receptor modulators in combination with estrogens | ENDORECHERCHE, INC. | 2002-12-26 | — | — | US | disclosed |
| EP-1251855-A1 | SELECTIVE ESTROGEN RECEPTOR MODULATORS IN COMBINATION WITH ESTROGENS | Endorecherche, Inc. (CA) | 2002-10-30 | — | — | EP | disclosed |
| US-6465445-B1 | SUCH AS DERIVATIVE CONTAINING PHENYL, BENZOPHENONE AND PYRROLIDINE OR PIPERIDINE RINGS AND DEHYDROEPIANDROSTERONE; TREATMENT AND/OR INHIBITION OF OSTEOPOROSIS, BREAST CANCER, HYPERCHOLESTEROLEMIA, HYPERLIPIDEMIA OR ATHEROSCLEROSIS | ENDORECHERCHE, INC. (CA) | 2002-10-15 | — | — | US | disclosed |
| WO-2001054699-A1 | SELECTIVE ESTROGEN RECEPTOR MODULATORS IN COMBINATION WITH ESTROGENS | ENDORECHERCHE, INC. (CA) | 2001-08-02 | — | — | WO | disclosed |
| EP-1083905-A2 | SELECTIVE ESTROGEN RECEPTOR MODULATOR IN COMBINATION WITH DEHYDROEPIANDROSTERONE (DHEA) OR ANALOGUES | Endorecherche Inc. (CA) | 2001-03-21 | — | — | EP | disclosed |
| WO-1999063974-A2 | SELECTIVE ESTROGEN RECEPTOR MODULATOR IN COMBINATION WITH DENYDROEPIANDROSTERONE (DHEA) OR ANALOGUES | ENDORECHERCHE, INC. (CA) | 1999-12-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040034000-A1 | Methods of treating and/or suppressing insulin resistance | SHBG, HSD17B11, HSD17B3 | MEN1 4020/4885KMT2A 4005/4885TNK2 4475/4885 |
| US-20190269697-A1 | A METHOD OF TREATING AND PREVENTING LOSS OF COGNITION | SHBG, BRCA1, CYP19A1 | MEN1 185/4885KMT2A 210/4885TNK2 3134/4885 |
| US-20030065008-A1 | Selective estrogen receptor modulators in combination with estrogens | ESR1, BRCA1, KISS1R | MEN1 54/4885KMT2A 691/4885TNK2 3158/4885 |
| US-20020198179-A1 | Selective estrogen receptor modulators in combination with estrogens | KISS1R, ESR1, BRCA1 | MEN1 48/4885KMT2A 716/4885TNK2 3166/4885 |
| US-20190269696-A1 | METHOD OF PREVENTING ALZHEIMIER'S DISEASE | BRCA1, SHBG, CYP19A1 | MEN1 97/4885KMT2A 187/4885TNK2 4303/4885 |
| US-10342805-B2 | Treatment of Alzheimer's disease, loss of cognition, memory loss and dementia with sex steroid precursors in combination with selective estrogen receptor modulators | BRCA1, SHBG, CYP19A1 | MEN1 224/4885KMT2A 159/4885TNK2 3091/4885 |
| US-10548903-B2 | Treatment of male androgen deficiency symptoms or diseases with sex steroid precursor combined with SERM | SHBG, CYP19A1, AR | MEN1 837/4885KMT2A 390/4885TNK2 3223/4885 |
| US-20170290847-A1 | TREATMENT OF MALE ANDROGEN DEFICIENCY SYMPTOMS OR DISEASES WITH SEX STEROID PRECURSOR COMBINED WITH SERM | SHBG, CYP19A1, AR | MEN1 837/4885KMT2A 390/4885TNK2 3223/4885 |
| US-20030040510-A1 | Selective estrogen receptor modulators in combination with estrogens | KISS1R, ESR1, BRCA1 | MEN1 48/4885KMT2A 716/4885TNK2 3166/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.