Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.58 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.57 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.54 |
| ▸ | PARP1 | P09874 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | SRC | P12931 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2854997 | 0.99 | SIGMAR1 (0.59) | L3MBTL1SIGMAR1PRMT1CYP19A1PARP1 | |
| SCHEMBL17374111 | 0.89 | PRMT1 (0.54) | L3MBTL1SIGMAR1PRMT1CYP19A1MAPK1 | |
| SCHEMBL1361813 | 0.88 | ALDH1A1 (0.64) | PRMT1MAPK1 | |
| SCHEMBL2498510 | 0.83 | L3MBTL1 (0.81) | L3MBTL1SIGMAR1PARP1KDM4ELMNA | |
| SCHEMBL5438202 | 0.82 | SIGMAR1 (0.73) | L3MBTL1SIGMAR1PRMT1KDM4ELMNA | |
| SCHEMBL4617661 | 0.82 | SFRP1 (0.61) | L3MBTL1SIGMAR1PARP1KDM4ELMNA | |
| Hydrochloric Acid SCHEMBL7966303 | 0.82 | L3MBTL1 (0.79) | L3MBTL1SIGMAR1PARP1KDM4ELMNA | |
| SCHEMBL6568486 | 0.82 | SIGMAR1 (0.72) | L3MBTL1SIGMAR1PARP1KDM4ELMNA | |
| SCHEMBL1565027 | 0.82 | PRMT1 (0.73) | PRMT1CYP19A1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL31174173 | 0.82 | PRMT1 (0.73) | PRMT1CYP19A1KDM4ELMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | disclosed |
| US-20080064690-A1 | PYRAZOLE-AMIDES AND -SULFONAMIDES | ICAGEN, INC. (US) | 2008-03-13 | — | — | US | disclosed |
| US-7223782-B2 | Pyrazole-amides and -sulfonamides | ICAGEN, INC. (US) | 2007-05-29 | — | — | US | disclosed |
| US-20050049237-A1 | Pyrazole-amides and -sulfonamides | ICAGEN, INC. (US) | 2005-03-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080064690-A1 | PYRAZOLE-AMIDES AND -SULFONAMIDES | SCN3A, TRPV3, HCN3 | L3MBTL1 4714/4885SIGMAR1 694/4885PRMT1 2611/4885 |
| US-20050049237-A1 | Pyrazole-amides and -sulfonamides | SCN3A, TRPV3, HCN3 | L3MBTL1 4714/4885SIGMAR1 694/4885PRMT1 2611/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.