Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | NPBWR1 | P48145 | 5/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | THPO | P40225 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2850337 | 0.92 | MAPT (0.40) | NTRK1PPARGNPBWR1CYP3A4CYP2C19 | |
| SCHEMBL2857582 | 0.89 | MAPT (0.42) | NTRK1NPBWR1NPSR1MAPTKMT2A | |
| SCHEMBL2860522 | 0.87 | MAPT (0.48) | NTRK1CYP3A4CYP2C19CYP1A2NPSR1 | |
| SCHEMBL2858533 | 0.86 | ATM (0.47) | NPBWR1CYP3A4CYP2C19CYP1A2PTGS2 | |
| SCHEMBL2858311 | 0.85 | RAB9A (0.47) | CYP3A4CYP2C19CYP2C9TSHRMAPT | |
| SCHEMBL2854533 | 0.84 | MEN1 (0.46) | CYP3A4CYP2C19CYP1A2NPSR1CYP2C9 | |
| SCHEMBL2852552 | 0.84 | MEN1 (0.51) | NPSR1MAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL2859712 | 0.83 | CA1 (0.45) | PTGS2PTGS1MAPTSMN1; SMN2 | |
| SCHEMBL2850809 | 0.82 | MAPT (0.43) | NPSR1TSHRMAPTKMT2AALDH1A1 | |
| SCHEMBL2859050 | 0.82 | PTGS1 (0.46) | NTRK1NPBWR1CYP3A4CYP2C19CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |