Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCQ | Q04759 | 2/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.31 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.30 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL285644 | 0.81 | PRKCQ (0.43) | PRKCQJAK2ROCK2PRKCDROCK1 | |
| SCHEMBL10276910 | 0.74 | PRKCQ (0.46) | PRKCQJAK2ROCK2PRKCDROCK1 | |
| SCHEMBL285150 | 0.67 | MAPK1 (0.40) | PRKCQJAK2ROCK2PRKCDROCK1 | |
| SCHEMBL2226447 | 0.66 | DRD2 (0.53) | MAPTKMT2A | |
| SCHEMBL285566 | 0.65 | CCNE2 (0.42) | MAPT | |
| SCHEMBL9937393 | 0.64 | PRKCQ (0.43) | PRKCQJAK2ROCK2PRKCDROCK1 | |
| SCHEMBL285196 | 0.63 | NUDT1 (0.33) | JAK2MEN1MAPTKMT2A | |
| SCHEMBL5930632 | 0.61 | ALDH1A1 (0.69) | MEN1MAPTKMT2A | |
| SCHEMBL28009248 | 0.61 | ALDH1A1 (0.44) | MEN1MAPTKMT2A | |
| SCHEMBL11341609 | 0.58 | KDM4E (0.45) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427464-A1 | PYRAZOLOPYRIDINES | Vertex Pharmaceuticals Incorporated (US) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010129668-A1 | PYRAZOLOPYRIDINES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-11-11 | — | — | WO | disclosed |