Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | LDLR | P01130 | 1/20 | 0.42 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.39 |
| ▸ | PRNP | P04156 | 1/20 | 0.39 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | NQO2 | P16083 | 1/20 | 0.39 |
| ▸ | HPGDS | O60760 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20670034 | 0.75 | GPR3 (0.54) | AURKAKDRAURKBLMNAKMT2A | |
| SCHEMBL13312790 | 0.67 | ALDH1A1 (0.59) | AURKAKDRAURKBLMNAKMT2A | |
| SCHEMBL10216426 | 0.67 | ALDH1A1 (0.63) | LMNAKMT2ASMN1; SMN2RXFP1PRNP | |
| SCHEMBL31223937 | 0.67 | KDM4E (0.53) | AURKAKDRAURKBLMNAKMT2A | |
| SCHEMBL7057607 | 0.67 | IMPDH2 (0.53) | LDLRPCSK9LMNAKMT2AIDO1 | |
| SCHEMBL20669941 | 0.65 | LMNA (0.46) | AURKAKDRAURKBLMNAKMT2A | |
| SCHEMBL15920627 | 0.65 | ALDH1A1 (0.51) | AURKAKDRAURKBTDP1LMNA | |
| SCHEMBL21939787 | 0.65 | KDM4E (0.55) | AURKAKDRAURKBLMNAKMT2A | |
| SCHEMBL30835552 | 0.65 | KDM4E (0.55) | AURKAKDRAURKBLMNAKMT2A | |
| SCHEMBL30901263 | 0.64 | KDM4E (0.49) | AURKAKDRAURKBLMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112424149-B | Synthesis of tipifanib | 库拉肿瘤学公司 | 2023-06-23 | — | — | CN | disclosed |
| CN-112424149-A | Synthesis of tipifarnib | 库拉肿瘤学公司 | 2021-02-26 | — | — | CN | disclosed |