Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | JMJD6 | Q6NYC1 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.37 |
| ▸ | GSK3A | P49840 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | HPGDS | O60760 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30403546 | 0.78 | EPHX2 (0.52) | EPHX2JMJD6L3MBTL1HCRTR1HCRTR2 | |
| SCHEMBL2713663 | 0.78 | EPHX2 (0.52) | EPHX2JMJD6L3MBTL1HCRTR1HCRTR2 | |
| SCHEMBL796410 | 0.77 | L3MBTL1 (0.60) | EPHX2JMJD6L3MBTL1GABRA5 | |
| SCHEMBL28864180 | 0.76 | EPHX2 (0.48) | EPHX2JMJD6L3MBTL1GSK3AGSK3B | |
| SCHEMBL28560721 | 0.76 | ATXN2 (0.41) | JMJD6GABRA5 | |
| SCHEMBL13875980 | 0.76 | EPHX2 (0.50) | EPHX2JMJD6L3MBTL1HCRTR1HCRTR2 | |
| SCHEMBL27913659 | 0.76 | EPHX2 (0.50) | EPHX2JMJD6L3MBTL1HCRTR1HCRTR2 | |
| SCHEMBL30281370 | 0.76 | EPHX2 (0.52) | EPHX2JMJD6L3MBTL1GSK3BKCNH2 | |
| SCHEMBL13890805 | 0.75 | EPHX2 (0.52) | EPHX2JMJD6L3MBTL1HCRTR1HCRTR2 | |
| SCHEMBL31191107 | 0.73 | EPHX2 (0.53) | EPHX2JMJD6L3MBTL1HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107922412-B | Bicyclic compounds as ATX inhibitors | 豪夫迈·罗氏有限公司 | 2021-02-23 | — | — | CN | disclosed |