SCHEMBL2852665

SCHEMBL2852665

CC(Cc1cc(C(C)(C)C)c(O)c(C(C)(C)C)c1)O[PH](=O)[O-].CC(Cc1cc(C(C)(C)C)c(O)c(C(C)(C)C)c1)O[PH](=O)[O-].[Ca+2]

nearest known ligand 0.50

Known targets — ChEMBL curated mechanism

GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHMGCRMMP1MMP13MMP7MMP8PTGS1PTGS2ileSpolrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HMGCR known ✓ P04035 2/20 0.50
GABBR2 known ✓ O75899 1/20 0.40
GABBR1 known ✓ Q9UBS5 1/20 0.40
KMT2A Q03164 5/20 0.41
ALDH1A1 P00352 5/20 0.41
MEN1 O00255 4/20 0.41
TSHR P16473 3/20 0.41
MAPK1 P28482 3/20 0.41
CYP1A2 P05177 2/20 0.41
CYP3A4 P08684 2/20 0.41
BLM P54132 2/20 0.41
ATM Q13315 2/20 0.41
HIF1A Q16665 2/20 0.41
NPSR1 Q6W5P4 2/20 0.41
MAPT P10636 2/20 0.41
USP2 O75604 1/20 0.41
CYP2D6 P10635 1/20 0.41
GAA P10253 5/20 0.41
LMNA P02545 2/20 0.41
GMNN O75496 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7184451 0.97 HMGCR (0.50) HMGCRKMT2AALDH1A1MEN1TSHR
SCHEMBL2279290 0.87 HMGCR (0.54) HMGCRKMT2AALDH1A1MEN1TSHR
SCHEMBL2279291 0.85 HMGCR (0.52) HMGCRKMT2AALDH1A1MEN1TSHR
SCHEMBL9455197 0.77 ALDH1A1 (0.46) HMGCRKMT2AALDH1A1MEN1TSHR
SCHEMBL269627 0.77 HMGCR (0.38) HMGCRKMT2AALDH1A1MEN1TSHR
SCHEMBL10426639 0.75 HMGCR (0.65) HMGCRKMT2AALDH1A1MEN1TSHR
SCHEMBL28846430 0.74 HMGCR (0.60) HMGCRKMT2AALDH1A1MEN1TSHR
SCHEMBL9162616 0.74 HMGCR (0.38) HMGCRKMT2AALDH1A1MEN1TSHR
SCHEMBL2861240 0.74 HMGCR (0.52) HMGCRKMT2AALDH1A1MEN1TSHR
SCHEMBL10426640 0.74 HMGCR (0.63) HMGCRKMT2AALDH1A1MEN1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2159274-B1 BRAKE FLUID CONTAINING TETRAZOLE CHIYODA CHEMICAL CO LTD (JP) 2013-04-17 EP disclosed
US-8357642-B2 Functional fluid CHIYODA CHEMICAL CO., LTD. (JP) 2013-01-22 US disclosed
US-20100137174-A1 FUNCTIONAL FLUID CHIYODA CHEMICAL CO., LTD. (JP) 2010-06-03 US disclosed
EP-2159274-A1 FUNCTIONAL FLUID Chiyoda Chemical Co. Ltd (JP) 2010-03-03 EP disclosed
EP-1406932-B1 QUICK CURING COMPOSITION KANEKA CORP (JP) 2007-12-12 EP disclosed
US-20040210019-A1 Quick curing compositions KANEKA CORPORATION (JP) 2004-10-21 US disclosed