Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CCR1 | P32246 | 2/20 | 0.36 |
| ▸ | ACHE | P22303 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | GPR6 | P46095 | 1/20 | 0.35 |
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.35 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.35 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.35 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.35 |
| ▸ | STIM2 | Q9P246 | 1/20 | 0.35 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.35 |
| ▸ | ACLY | P53396 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2852820 | 0.90 | TMPRSS4 (0.45) | MAPTNPSR1NPC1RAB9ATP53 | |
| SCHEMBL2850610 | 0.88 | MAPT (0.40) | MAPTTP53CCR1ACHESMN1; SMN2 | |
| SCHEMBL2848538 | 0.85 | MAPT (0.45) | MAPTNPSR1NPC1RAB9ATP53 | |
| SCHEMBL2860522 | 0.85 | MAPT (0.48) | MAPTNPSR1NPC1RAB9ACCR1 | |
| SCHEMBL2857550 | 0.85 | TMPRSS4 (0.45) | MAPTNPSR1NPC1RAB9ACCR1 | |
| SCHEMBL2856901 | 0.83 | MAPT (0.40) | MAPTNPSR1NPC1RAB9ATP53 | |
| SCHEMBL2850809 | 0.82 | MAPT (0.43) | MAPTNPSR1RAB9ATP53CCR1 | |
| SCHEMBL2854533 | 0.81 | MEN1 (0.46) | MAPTNPSR1NPC1RAB9AACHE | |
| SCHEMBL2857582 | 0.81 | MAPT (0.42) | MAPTNPSR1NPC1RAB9ATP53 | |
| SCHEMBL2853465 | 0.81 | RAB9A (0.44) | MAPTNPSR1NPC1RAB9ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |