Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | CCR1 | P32246 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | XPO1 | O14980 | 1/20 | 0.37 |
| ▸ | GPR6 | P46095 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2860522 | 0.91 | MAPT (0.48) | MAPTNPSR1RAB9ANPC1CCR1 | |
| SCHEMBL2857550 | 0.91 | TMPRSS4 (0.45) | TMPRSS4MAPTNPSR1RAB9ANPC1 | |
| SCHEMBL2852809 | 0.90 | MAPT (0.39) | TMPRSS4MAPTNPSR1RAB9ANPC1 | |
| SCHEMBL2856901 | 0.89 | MAPT (0.40) | MAPTNPSR1RAB9ANPC1CCR1 | |
| SCHEMBL2854596 | 0.87 | TP53 (0.46) | MAPTNPSR1CCR1ALDH1A1HTT | |
| SCHEMBL2853065 | 0.85 | NR3C1 (0.46) | MAPTNPSR1RAB9ANPC1ALDH1A1 | |
| SCHEMBL2854533 | 0.84 | MEN1 (0.46) | MAPTNPSR1RAB9ANPC1GPR6 | |
| SCHEMBL2854221 | 0.83 | MAPT (0.51) | TMPRSS4MAPTNPSR1CCR1ALDH1A1 | |
| SCHEMBL2857353 | 0.82 | CCR1 (0.47) | MAPTCCR1ALDH1A1GPR6ACHE | |
| SCHEMBL2852244 | 0.82 | MAPT (0.48) | MAPTNPSR1ALDH1A1GPR6ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |