Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAM | O43451 | 7/20 | 0.64 |
| ▸ | GAA | P10253 | 7/20 | 0.64 |
| ▸ | SI | P14410 | 7/20 | 0.64 |
| ▸ | MGAM2 | Q2M2H8 | 7/20 | 0.64 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.61 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.61 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.61 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28519198 | 0.89 | MEN1 (0.66) | MGAMGAASIMGAM2GPR84 | |
| SCHEMBL5186684 | 0.87 | CYP2D6 (0.67) | MGAMGAASIMGAM2GPR84 | |
| SCHEMBL7967556 | 0.86 | GPR84 (0.62) | MGAMGAASIMGAM2GPR84 | |
| SCHEMBL28528875 | 0.85 | MGAM (0.51) | MGAMGAASIMGAM2GPR84 | |
| SCHEMBL14168804 | 0.84 | GPR84 (0.64) | MGAMGAASIMGAM2GPR84 | |
| SCHEMBL13253129 | 0.83 | MEN1 (0.74) | MGAMGAASIMGAM2GPR84 | |
| SCHEMBL27682946 | 0.83 | GPR84 (0.62) | MGAMGAASIMGAM2GPR84 | |
| SCHEMBL15148952 | 0.82 | MGAM (0.76) | MGAMGAASIMGAM2GPR84 | |
| SCHEMBL2073813 | 0.80 | CYP2D6 (0.67) | MGAMGAASIMGAM2GPR84 | |
| SCHEMBL108954 | 0.80 | GPR84 (0.84) | MGAMGAASIMGAM2GPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12486228-B2 | N-substituted indoles and use as allosteric modulators of cannabinoid receptors | NORTHEASTERN UNIVERSITY (US) | 2025-12-02 | — | — | US | disclosed |
| US-20210355084-A1 | N-SUBSTITUTED INDOLES AND USE AS ALLOSTERIC MODULATORS OF CANNABINOID RECEPTORS | NORTHEASTERN UNIVERSITY | 2021-11-18 | — | — | US | disclosed |
| US-20210355084-A1 | N-SUBSTITUTED INDOLES AND USE AS ALLOSTERIC MODULATORS OF CANNABINOID RECEPTORS | NORTHEASTERN UNIVERSITY | 2021-11-18 | — | — | US | disclosed |
| EP-3813825-A1 | N-SUBSTITUTED INDOLES AND USE AS ALLOSTERIC MODULATORS OF CANNABINOID RECEPTORS | Northeastern University (US) | 2021-05-05 | — | — | EP | disclosed |
| US-8063234-B2 | Substituted 7-sulfanylmethyl-, 7-sulfinylmethyl- and 7-sulfonylmethylindoles and the use thereof | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2011-11-22 | — | — | US | disclosed |
| US-20110201564-A1 | SUBSTITUTED 7-SULFANYLMETHYL, 7-SULFINYLMETHYL AND 7-SULFONYLMETHYL INDOLES AND USE THEREOF | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2011-08-18 | — | — | US | disclosed |
| US-20110183928-A1 | 3-Cyanoalkyl- and 3-hydroxyalkylindoles and use thereof | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2011-07-28 | — | — | US | disclosed |
| CN-102131776-A | Substituted 7-sulfanylmethyl, 7-sulfinylmethyl and 7-sulfonylmethyl indoles and use thereof | BAYER SCHERING PHARMA AG | 2011-07-20 | — | — | CN | disclosed |
| US-20100105744-A1 | SUBSTITUTED 7-SULFANYLMETHYL-, 7-SULFINYLMETHYL- AND 7-SULFONYLMETHYLINDOLES AND THE USE THEREOF | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-04-29 | — | — | US | disclosed |
| CN-1230163-C | 2-phenyl-1- [4- (2-aminoethoxy) -benzyl ] -indole in combination with an estrogen | AMERICAN HOME PROD (US) | 2005-12-07 | — | — | CN | disclosed |
| US-6924281-B2 | 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indoles as estrogenic agents | WYETH (US) | 2005-08-02 | — | — | US | disclosed |
| US-20050026905-A1 | 2-Phenyl-1-[4-(2-aminoethoxy)-benzyl]-indoles as estrogenic agents | WYETH (US) | 2005-02-03 | — | — | US | disclosed |
| CN-1326347-A | 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole in combination with estrogens | AMERICAN HOME PROD (US) | 2001-12-12 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100105744-A1 | SUBSTITUTED 7-SULFANYLMETHYL-, 7-SULFINYLMETHYL- AND 7-SULFONYLMETHYLINDOLES AND THE USE THEREOF | STS, HTR7, PCSK7 | MGAM 457/4885GAA 944/4885SI 106/4885 |
| US-12486228-B2 | N-substituted indoles and use as allosteric modulators of cannabinoid receptors | CNR2, CNR1, GPR18 | MGAM 2317/4885GAA 3469/4885SI 4277/4885 |
| US-20110201564-A1 | SUBSTITUTED 7-SULFANYLMETHYL, 7-SULFINYLMETHYL AND 7-SULFONYLMETHYL INDOLES AND USE THEREOF | HTR7, STS, INMT | MGAM 735/4885GAA 2822/4885SI 98/4885 |
| US-20210355084-A1 | N-SUBSTITUTED INDOLES AND USE AS ALLOSTERIC MODULATORS OF CANNABINOID RECEPTORS | CNR2, CNR1, GPR18 | MGAM 2317/4885GAA 3469/4885SI 4277/4885 |
| US-20050026905-A1 | 2-Phenyl-1-[4-(2-aminoethoxy)-benzyl]-indoles as estrogenic agents | ESR2, ESR1, GPER1 | MGAM 4704/4885GAA 4070/4885SI 3879/4885 |
| US-20110183928-A1 | 3-Cyanoalkyl- and 3-hydroxyalkylindoles and use thereof | HTR3C, HTR3A, ADRB3 | MGAM 1508/4885GAA 1169/4885SI 369/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.