Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 5/20 | 0.48 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | CCR1 | P32246 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.38 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2857987 | 0.93 | CNR1 (0.43) | P2RX7ABCB11TRPV1CCR1RXFP1 | |
| SCHEMBL2856697 | 0.93 | KDM4E (0.46) | P2RX7ABCB11TRPV1RXFP1KDM4E | |
| SCHEMBL2854563 | 0.90 | P2RX7 (0.57) | P2RX7CCR1KDM4EALDH1A1NR3C1 | |
| SCHEMBL2848513 | 0.90 | P2RX7 (0.43) | P2RX7TRPV1CCR1KDM4EALDH1A1 | |
| SCHEMBL2854496 | 0.90 | P2RX7 (0.47) | P2RX7TRPV1CCR1KDM4EALDH1A1 | |
| SCHEMBL2853184 | 0.89 | P2RX7 (0.54) | P2RX7TRPV1KDM4EALDH1A1 | |
| SCHEMBL2856750 | 0.89 | P2RX7 (0.42) | P2RX7CCR1RXFP1KDM4EALDH1A1 | |
| SCHEMBL2858012 | 0.87 | CNR1 (0.46) | P2RX7TRPV1CCR1RXFP1KDM4E | |
| SCHEMBL2854346 | 0.86 | MAPT (0.52) | P2RX7CCR1RXFP1KDM4EALDH1A1 | |
| SCHEMBL2859365 | 0.85 | CNR1 (0.49) | P2RX7KDM4EALDH1A1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |