Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 7/20 | 0.46 |
| ▸ | CASR | P41180 | 2/20 | 0.43 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.41 |
| ▸ | CCNC | P24863 | 3/20 | 0.41 |
| ▸ | CDK8 | P49336 | 3/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | BCR | P11274 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2857649 | 0.92 | NOTUM (0.51) | CHRM4CASRNOTUMCHRM2CHRM1 | |
| SCHEMBL2854779 | 0.84 | SMO (0.49) | CASRNOTUM | |
| SCHEMBL2859595 | 0.78 | CHRM4 (0.53) | CHRM4CHRM2CHRM1CHRM5CHRM3 | |
| SCHEMBL22815701 | 0.75 | CHRM4 (0.49) | CHRM4CASRSMPD3CCNCCDK8 | |
| SCHEMBL14989237 | 0.74 | MAPK13 (0.44) | MAPTNPC1NFKB1RAB9ANFKB2 | |
| SCHEMBL2854465 | 0.72 | RAB9A (0.47) | MAPTNPC1NFKB1RAB9ANFKB2 | |
| SCHEMBL31288311 | 0.71 | CHRM4 (0.58) | CHRM4EPHX2MAPTSMN1; SMN2 | |
| SCHEMBL5138185 | 0.71 | FAAH (0.41) | MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL2856979 | 0.70 | RAB9A (0.46) | MAPTNPC1NFKB1RAB9ANFKB2 | |
| SCHEMBL23484542 | 0.70 | MAP4K4 (0.49) | CHRM4EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |