Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 12/20 | 0.53 |
| ▸ | BCHE | P06276 | 2/20 | 0.52 |
| ▸ | ACHE | P22303 | 2/20 | 0.52 |
| ▸ | BACE1 | P56817 | 2/20 | 0.52 |
| ▸ | CCR2 | P41597 | 1/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.47 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 3/20 | 0.47 |
| ▸ | HTR2A | P28223 | 2/20 | 0.47 |
| ▸ | DRD2 | P14416 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2854763 | 0.91 | DRD4 (0.50) | BCHEACHEBACE1CCR2DRD4 | |
| SCHEMBL2857724 | 0.86 | SIGMAR1 (0.53) | CHRM4 | |
| SCHEMBL2863246 | 0.85 | DRD4 (0.49) | CCR2DRD4DRD2 | |
| SCHEMBL2858617 | 0.85 | CHRM4 (0.58) | CHRM4BCHEACHEBACE1CHRM2 | |
| SCHEMBL2857980 | 0.84 | DRD4 (0.47) | CHRM4CCR2DRD4DRD2 | |
| SCHEMBL2856452 | 0.83 | DRD4 (0.47) | CCR2DRD4DRD2 | |
| SCHEMBL2854450 | 0.78 | CHRM4 (0.46) | CHRM4CHRM2CHRM1CHRM5CHRM3 | |
| SCHEMBL2854556 | 0.76 | DRD4 (0.47) | BACE1DRD4DRD2 | |
| SCHEMBL2852970 | 0.75 | DRD2 (0.51) | CCR2DRD4DRD2 | |
| SCHEMBL25153723 | 0.74 | EPHX2 (0.73) | CHRM4BCHEACHEBACE1DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |