Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 4/20 | 0.44 |
| ▸ | CA1 | P00915 | 4/20 | 0.44 |
| ▸ | CA2 | P00918 | 4/20 | 0.44 |
| ▸ | CA4 | P22748 | 4/20 | 0.44 |
| ▸ | CA7 | P43166 | 4/20 | 0.44 |
| ▸ | CA9 | Q16790 | 4/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.41 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2861567 | 0.89 | MALT1 (0.41) | CA12CA1CA2CA4CA7 | |
| SCHEMBL2857601 | 0.86 | LMNA (0.37) | LMNAHTTEPHX2MAPTNPC1 | |
| SCHEMBL2854592 | 0.85 | MEN1 (0.40) | KDM4ESMN1; SMN2LMNAEPHX2MAPT | |
| SCHEMBL2862993 | 0.85 | MEN1 (0.41) | CA1CA2CA7CA9KDM4E | |
| SCHEMBL2862974 | 0.84 | KEAP1 (0.50) | KDM4ESMN1; SMN2LMNAEPHX2MAPT | |
| SCHEMBL2856385 | 0.83 | CCR1 (0.44) | CA1CA2CA4CA7LMNA | |
| SCHEMBL2856588 | 0.82 | KEAP1 (0.42) | CA12CA1CA2CA9KDM4E | |
| SCHEMBL2855716 | 0.82 | KEAP1 (0.46) | SMN1; SMN2LMNAHTTMAPK1MAPT | |
| SCHEMBL2855798 | 0.82 | MAPT (0.45) | CA1CA2CA4CA7SMN1; SMN2 | |
| SCHEMBL2860990 | 0.81 | KEAP1 (0.43) | TRPV1LMNAEPHX2MAPTRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |