Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MALT1 | Q9UDY8 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
| ▸ | SLC11A2 | P49281 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2854592 | 0.90 | MEN1 (0.40) | MALT1SMN1; SMN2JAK1TYK2ALDH1A1 | |
| SCHEMBL2854463 | 0.89 | CA12 (0.44) | SMN1; SMN2MAPK1L3MBTL1LMNAMEN1 | |
| SCHEMBL2862993 | 0.88 | MEN1 (0.41) | MALT1SMN1; SMN2ALDH1A1KEAP1NFE2L2 | |
| SCHEMBL2862974 | 0.87 | KEAP1 (0.50) | SMN1; SMN2ALDH1A1KEAP1NFE2L2LMNA | |
| SCHEMBL2854810 | 0.86 | KMT2A (0.46) | MALT1ALDH1A1SLC11A2L3MBTL1LMNA | |
| SCHEMBL2857895 | 0.85 | GRM4 (0.48) | MALT1SMN1; SMN2MAPK1ALDH1A1SLC11A2 | |
| SCHEMBL2857601 | 0.85 | LMNA (0.37) | MALT1ALDH1A1KEAP1NFE2L2LMNA | |
| SCHEMBL2856385 | 0.84 | CCR1 (0.44) | KEAP1NFE2L2LMNARXFP1CA1 | |
| SCHEMBL2856588 | 0.83 | KEAP1 (0.42) | SMN1; SMN2MAPK1ALDH1A1KEAP1NFE2L2 | |
| SCHEMBL2855798 | 0.83 | MAPT (0.45) | SMN1; SMN2ALDH1A1KEAP1NFE2L2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |