Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 2/20 | 0.50 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.50 |
| ▸ | BRAF | P15056 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | MST1R | Q04912 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2856385 | 0.93 | CCR1 (0.44) | KEAP1NFE2L2BRAFCARM1EPHX2 | |
| SCHEMBL2855798 | 0.92 | MAPT (0.45) | KEAP1NFE2L2MAPTSMN1; SMN2KMT2A | |
| SCHEMBL2855716 | 0.92 | KEAP1 (0.46) | KEAP1NFE2L2BRAFPOLBMAPT | |
| SCHEMBL2856588 | 0.92 | KEAP1 (0.42) | KEAP1NFE2L2BRAFMAPTSMN1; SMN2 | |
| SCHEMBL2853595 | 0.90 | LMNA (0.44) | KEAP1NFE2L2MAPTSMN1; SMN2KDM4E | |
| SCHEMBL2869545 | 0.89 | KEAP1 (0.40) | KEAP1NFE2L2BRAFMAPTSMN1; SMN2 | |
| SCHEMBL2860990 | 0.89 | KEAP1 (0.43) | KEAP1NFE2L2MAPTKMT2ACARM1 | |
| SCHEMBL2852487 | 0.89 | MAPT (0.48) | KEAP1NFE2L2MAPTSMN1; SMN2KMT2A | |
| SCHEMBL2854592 | 0.88 | MEN1 (0.40) | KEAP1NFE2L2MAPTSMN1; SMN2KMT2A | |
| SCHEMBL2861567 | 0.87 | MALT1 (0.41) | KEAP1NFE2L2MAPTSMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |