Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 8/20 | 0.47 |
| ▸ | DRD2 | P14416 | 5/20 | 0.47 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.46 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
| ▸ | MME | P08473 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.43 |
| ▸ | MC4R | P32245 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15889273 | 0.79 | POLB (0.58) | DRD4SIGMAR1 | |
| SCHEMBL2854763 | 0.78 | DRD4 (0.50) | DRD4DRD2BACE1SIGMAR1 | |
| SCHEMBL2859595 | 0.76 | CHRM4 (0.53) | DRD4DRD2BACE1 | |
| SCHEMBL2863246 | 0.76 | DRD4 (0.49) | DRD4DRD2MCHR1SIGMAR1 | |
| SCHEMBL2854713 | 0.75 | NTRK1 (0.49) | — | |
| SCHEMBL10155707 | 0.75 | MCHR1 (0.61) | DRD4DRD2MCHR1SIGMAR1 | |
| SCHEMBL2856997 | 0.74 | ALDH1A1 (0.57) | — | |
| SCHEMBL2857980 | 0.74 | DRD4 (0.47) | DRD4DRD2MCHR1SIGMAR1 | |
| SCHEMBL2850487 | 0.74 | HTT (0.48) | — | |
| SCHEMBL2856452 | 0.74 | DRD4 (0.47) | DRD4DRD2MCHR1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |