Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 1/20 | 0.54 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | LTA4H | P09960 | 2/20 | 0.50 |
| ▸ | PPARG | P37231 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.49 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7037985 | 0.92 | ADRB2 (0.53) | ADRB2ADRB1LMNAL3MBTL1LTA4H | |
| SCHEMBL2159817 | 0.91 | LTA4H (0.50) | ADRB2ADRB1LMNAL3MBTL1LTA4H | |
| SCHEMBL4944581 | 0.91 | ADRB2 (0.52) | ADRB2ADRB1LMNAL3MBTL1LTA4H | |
| SCHEMBL2170785 | 0.90 | FFAR1 (0.50) | ADRB2ADRB1LMNAL3MBTL1LTA4H | |
| SCHEMBL7528179 | 0.86 | LMNA (0.62) | ADRB2ADRB1LMNAL3MBTL1FFAR1 | |
| SCHEMBL1495266 | 0.84 | ADRB2 (0.54) | ADRB2ADRB1LMNAL3MBTL1LTA4H | |
| SCHEMBL27545059 | 0.84 | ADRB2 (0.54) | ADRB2ADRB1LMNAL3MBTL1LTA4H | |
| SCHEMBL13932451 | 0.84 | FFAR1 (0.60) | ADRB2ADRB1LMNAL3MBTL1LTA4H | |
| SCHEMBL28543599 | 0.84 | ADRB2 (0.54) | ADRB2ADRB1LMNAL3MBTL1LTA4H | |
| SCHEMBL2437986 | 0.84 | ALDH1A1 (0.54) | LMNAL3MBTL1LTA4HKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108239029-B | Preparation and medical application of tetrahydroisoquinoline compounds and salts thereof | 中国医学科学院药物研究所 | 2021-04-13 | — | — | CN | disclosed |