Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY1 | P47900 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | IDH1 | O75874 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GPR6 | P46095 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | AHR | P35869 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2850763 | 0.92 | MAPT (0.48) | P2RY1MAPTPOLBSMN1; SMN2KDM4E | |
| SCHEMBL2858606 | 0.91 | P2RY1 (0.47) | P2RY1MAPTPOLBSMN1; SMN2KDM4E | |
| SCHEMBL2852552 | 0.89 | MEN1 (0.51) | MAPTPOLBSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL2854596 | 0.88 | TP53 (0.46) | MAPTPOLBSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL2848541 | 0.88 | RAB9A (0.43) | MAPTPOLBSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL2859508 | 0.87 | CYP1A2 (0.46) | P2RY1MAPTPOLBSMN1; SMN2KDM4E | |
| SCHEMBL2850610 | 0.85 | MAPT (0.40) | MAPTPOLBSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL2857721 | 0.85 | ALDH1A1 (0.52) | P2RY1MAPTPOLBSMN1; SMN2KDM4E | |
| SCHEMBL2857074 | 0.84 | LPAR1 (0.42) | MAPTPOLBSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL2858110 | 0.84 | KDM4E (0.44) | MAPTPOLBSMN1; SMN2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |