Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 7/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.35 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methyl Alcohol SCHEMBL28295123 | 0.81 | — | — | |
| SCHEMBL284612 | 0.81 | — | — | |
| SCHEMBL28235810 | 0.81 | — | — | |
| SCHEMBL22837 | 0.81 | — | — | |
| Alcohol SCHEMBL28287486 | 0.79 | ALDH1A1 (0.30) | TSHRALDH1A1 | |
| SCHEMBL688180 | 0.77 | TSHR (0.45) | TSHRALDH1A1HSD17B10 | |
| Fumaric Acid SCHEMBL1967229 | 0.76 | HCAR2 (0.38) | HCAR2TSHRTP53EGLN1EGLN3 | |
| SCHEMBL28302030 | 0.74 | — | — | |
| SCHEMBL2262727 | 0.73 | GABRP (0.38) | HCAR2 | |
| SCHEMBL2234580 | 0.73 | GABRP (0.38) | HCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110511672-B | Bottom-coating active siloxane composition and preparation method and application thereof | 广东普赛达密封粘胶有限公司 | 2021-05-04 | — | — | CN | disclosed |
| CN-110511672-A | A kind of primary coat activity silicone composition and its preparation method and application | GUANGDONG PUSTAR ADHESIVES & SEALANTS CO LTD | 2019-11-29 | — | — | CN | disclosed |