SCHEMBL28563045

SCHEMBL28563045

NC(=O)Oc1cnc(Cl)c(F)c1I

nearest known ligand 0.31

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CCNC P24863 1/20 0.31
CDK8 P49336 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28903820 0.81 CCNC (0.31) CCNCCDK8
SCHEMBL29149648 0.81 CCNC (0.33) CCNCCDK8
SCHEMBL28549352 0.78 KIF11 (0.33)
SCHEMBL29149630 0.77
SCHEMBL26988747 0.75 SCN9A (0.32)
SCHEMBL24386892 0.74 ALDH1A1 (0.33)
SCHEMBL17479501 0.73 MEN1 (0.32)
SCHEMBL28544455 0.73 HTR5A (0.33) CCNCCDK8
SCHEMBL27910465 0.73 SMN1; SMN2 (0.33)
Methoxymethane SCHEMBL25337731 0.73 NNMT (0.40)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112638898-B Heteroaryl substituted sulfonamide compounds and their use as sodium channel inhibitors 泽农医药公司 2024-04-09 CN disclosed
CN-114249753-A Triazolopyridine kinase inhibitors 山东轩竹医药科技有限公司 2022-03-29 CN disclosed
CN-112638898-A Heteroaryl substituted sulfonamide compounds and their use as sodium channel inhibitors 泽农医药公司 2021-04-09 CN disclosed