Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | GPR3 | P46089 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | FDPS | P14324 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HTR3A | P46098 | 1/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7034328 | 0.83 | TLR8 (0.33) | TLR8CYP1A2KDM4EALDH1A1RAB9A | |
| SCHEMBL1591908 | 0.72 | NCF1 (0.52) | CYP1A2KDM4EALDH1A1RAB9ANPC1 | |
| SCHEMBL12003727 | 0.72 | CYP1A2 (0.56) | CYP1A2KDM4EALDH1A1HPGDGPR3 | |
| SCHEMBL31391395 | 0.72 | CYP1A2 (0.56) | CYP1A2KDM4EALDH1A1HPGDGPR3 | |
| SCHEMBL5675046 | 0.71 | FGFR4 (0.45) | CYP1A2KDM4ERAB9AGPR3 | |
| SCHEMBL983301 | 0.70 | KDM4E (0.38) | TLR8CYP1A2KDM4EALDH1A1RAB9A | |
| SCHEMBL3261534 | 0.69 | CRHR1 (0.36) | KDM4EALDH1A1POLBCRHR1MAPT | |
| SCHEMBL23978672 | 0.69 | CYP1A2 (0.45) | TLR8CYP1A2KDM4ERAB9AGPR3 | |
| SCHEMBL3337226 | 0.68 | CYP1A2 (0.47) | CYP1A2KDM4EALDH1A1HPGDGPR3 | |
| SCHEMBL17061539 | 0.68 | CYP1A2 (0.47) | CYP1A2KDM4EALDH1A1HPGDGPR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107827877-B | Dialkylamino quinazoline compound and application thereof in preparation of antitumor drugs | 陕西师范大学 | 2021-05-07 | — | — | CN | claimed |
| CN-109096254-B | Quinazoline derivative and preparation method and application thereof | 江西师范大学 | 2021-07-06 | — | — | CN | disclosed |
| CN-107827877-B | Dialkylamino quinazoline compound and application thereof in preparation of antitumor drugs | 陕西师范大学 | 2021-05-07 | — | — | CN | disclosed |
| CN-107827877-B | Dialkylamino quinazoline compound and application thereof in preparation of antitumor drugs | 陕西师范大学 | 2021-05-07 | — | — | CN | disclosed |