Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 2/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 8/20 | 0.41 |
| ▸ | CDK2 | P24941 | 8/20 | 0.41 |
| ▸ | CDK7 | P50613 | 8/20 | 0.41 |
| ▸ | CCNH | P51946 | 8/20 | 0.41 |
| ▸ | MNAT1 | P51948 | 8/20 | 0.41 |
| ▸ | CCNK | O75909 | 7/20 | 0.41 |
| ▸ | CDK12 | Q9NYV4 | 7/20 | 0.41 |
| ▸ | MGAM | O43451 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.35 |
| ▸ | AKT1 | P31749 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.33 |
| ▸ | GPR3 | P46089 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28565830 | 0.71 | TLR8 (0.37) | CYP1A2RAB9AKDM4EGPR3 | |
| SCHEMBL31391395 | 0.70 | CYP1A2 (0.56) | CYP1A2KDM4ELMNAGPR3 | |
| SCHEMBL12003727 | 0.70 | CYP1A2 (0.56) | CYP1A2KDM4ELMNAGPR3 | |
| SCHEMBL28347290 | 0.70 | MAP3K5 (0.41) | FGFR4CCNA2CDK2CCNKCDK12 | |
| SCHEMBL27864952 | 0.69 | ALDH1A1 (0.35) | FGFR4CCNA2CDK2CDK7CCNH | |
| SCHEMBL6524322 | 0.69 | CCNA2 (0.57) | CCNA2CDK2CDK7CCNHMNAT1 | |
| SCHEMBL7034328 | 0.69 | TLR8 (0.33) | FGFR4CCNA2CDK2CDK7CCNH | |
| SCHEMBL29427872 | 0.67 | MGAM (0.50) | MGAMMAP3K5RAB9AKDM4ELMNA | |
| SCHEMBL2337793 | 0.67 | MGAM (0.50) | MGAMMAP3K5RAB9AKDM4ELMNA | |
| SCHEMBL11292161 | 0.67 | RAB9A (0.38) | CCNA2CDK2CDK7CCNHMNAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1745073-A | Preparation of substituted quinazolines | WARNER LAMBERT CO (US) | 2006-03-08 | — | — | CN | disclosed |
| EP-1618095-A2 | PREPARATION OF SUBSTITUTED QUINAZOLINES | Warner-Lambert Company LLC (US) | 2006-01-25 | — | — | EP | disclosed |
| WO-2004069791-A3 | PREPARATION OF SUBSTITUTED QUINAZOLINES | WARNER LAMBERT CO (US) | 2004-12-16 | — | — | WO | disclosed |
| WO-2004069791-A2 | PREPARATION OF SUBSTITUTED QUINAZOLINES | WARNER-LAMBERT COMPANY LLC (US) | 2004-08-19 | — | — | WO | disclosed |
| US-20040158065-A1 | Preparation of substituted quinazolines | BARTH HUBERT (DE) | 2004-08-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040158065-A1 | Preparation of substituted quinazolines | RAF1, CDKN1A, MAP3K1 | FGFR4 1448/4885CCNA2 397/4885CDK2 13/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.