Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.48 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2856049 | 0.86 | ATM (0.53) | KDM4ESCN5ASCN9AMAPTSMN1; SMN2 | |
| SCHEMBL2859981 | 0.82 | KDM4E (0.50) | KDM4EKCNMA1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL2856664 | 0.80 | CYP1A2 (0.55) | KDM4EKMT2AMAPTSMN1; SMN2THRB | |
| SCHEMBL2857721 | 0.80 | ALDH1A1 (0.52) | KDM4EKMT2AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL2858063 | 0.79 | MAPT (0.57) | KDM4EMAPTSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL2856134 | 0.78 | RAB9A (0.60) | KDM4EKMT2ASCN9AMAPTSMN1; SMN2 | |
| SCHEMBL2850019 | 0.78 | ROCK2 (0.46) | MAPTSMN1; SMN2TP53ALDH1A1LMNA | |
| SCHEMBL2859050 | 0.77 | PTGS1 (0.46) | KDM4EHIF1AKMT2AMAPTSMN1; SMN2 | |
| SCHEMBL2859651 | 0.77 | MAPT (0.46) | KDM4EKMT2AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL2854169 | 0.76 | MAPT (0.56) | KDM4EKMT2AMAPTSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | disclosed |