Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 8/20 | 0.52 |
| ▸ | P2RX1 | P51575 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TACR1 | P25103 | 1/20 | 0.46 |
| ▸ | MALT1 | Q9UDY8 | 5/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2859043 | 0.93 | CCR1 (0.62) | CCR1LMNAMALT1ALDH1A1 | |
| SCHEMBL2848347 | 0.90 | GAA (0.51) | CCR1MALT1HTTKDM4EALDH1A1 | |
| SCHEMBL2855247 | 0.86 | CCR1 (0.49) | CCR1MALT1 | |
| SCHEMBL2852396 | 0.84 | LMNA (0.45) | CCR1P2RX1LMNATACR1ALDH1A1 | |
| SCHEMBL2854304 | 0.83 | NPC1 (0.49) | CCR1LMNAKDM4EALDH1A1 | |
| SCHEMBL2852112 | 0.83 | CCR1 (0.68) | CCR1P2RX1KDM4EALDH1A1TMPRSS4 | |
| SCHEMBL2854060 | 0.82 | KDM4E (0.65) | CCR1TACR1KDM4EALDH1A1 | |
| SCHEMBL2855124 | 0.80 | KDM4E (0.47) | P2RX1MALT1KDM4EALDH1A1 | |
| SCHEMBL2857071 | 0.79 | CCR1 (0.57) | CCR1P2RX1TACR1KDM4EALDH1A1 | |
| SCHEMBL2852100 | 0.79 | MAPK11 (0.49) | MALT1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | disclosed |