SCHEMBL28609758

SCHEMBL28609758

COC(=O)C(Cc1ccccc1)NC(=O)c1cccc([N+](=O)[O-])c1

nearest known ligand 0.62

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.61
MAPK1 P28482 1/20 0.57
HPGD P15428 2/20 0.56
SMN1; SMN2 Q16637 2/20 0.56
RAB9A P51151 3/20 0.56
GAA P10253 1/20 0.56
LMNA P02545 1/20 0.55
GLA P06280 1/20 0.55
NPC1 O15118 1/20 0.53
TP53 P04637 1/20 0.53
THRB P10828 1/20 0.52
CYP2C9 P11712 1/20 0.52
CYP2C19 P33261 1/20 0.52
HSD17B10 Q99714 1/20 0.52
MEN1 O00255 1/20 0.52
KMT2A Q03164 1/20 0.52
LNPEP Q9UIQ6 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28604598 0.87 RAB9A (0.70) ALDH1A1SMN1; SMN2RAB9AGAALMNA
SCHEMBL20514969 0.86 SMN1; SMN2 (0.60) ALDH1A1SMN1; SMN2LMNATHRBCYP2C9
SCHEMBL20514968 0.86 SMN1; SMN2 (0.60) ALDH1A1SMN1; SMN2LMNATHRBCYP2C9
SCHEMBL4368609 0.84 RAB9A (0.60) ALDH1A1SMN1; SMN2RAB9AGAALMNA
SCHEMBL4362723 0.83 ALDH1A1 (0.59) ALDH1A1SMN1; SMN2RAB9AGAALMNA
SCHEMBL1793176 0.83 GAA (0.76) ALDH1A1RAB9AGAALMNAGLA
SCHEMBL2461492 0.83 GAA (0.76) ALDH1A1RAB9AGAALMNAGLA
SCHEMBL31206887 0.83 GAA (0.76) ALDH1A1RAB9AGAALMNAGLA
SCHEMBL4180329 0.82 ALDH1A1 (0.67) ALDH1A1RAB9AGAALMNAGLA
SCHEMBL17964202 0.81 LNPEP (0.54) ALDH1A1SMN1; SMN2RAB9AGAAGLA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106008665-B Compound with tumor proliferation inhibition function and preparation method and application thereof 北京大学 2021-03-16 CN disclosed