Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 14/20 | 0.48 |
| ▸ | EED | O75530 | 1/20 | 0.48 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.48 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.48 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.46 |
| ▸ | EZH1 | Q92800 | 3/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28595150 | 0.85 | EZH2 (0.46) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL28613717 | 0.84 | SMN1; SMN2 (0.52) | EZH2EZH1KDM4EALDH1A1HSD17B10 | |
| SCHEMBL29473822 | 0.84 | SMN1; SMN2 (0.52) | EZH2EZH1KDM4EALDH1A1HSD17B10 | |
| SCHEMBL29473820 | 0.83 | ROCK2 (0.49) | EZH2ROCK2ROCK1 | |
| SCHEMBL30021488 | 0.80 | EZH2 (0.50) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL28601010 | 0.78 | EZH2 (0.45) | EZH2ROCK2ROCK1EZH1ALDH1A1 | |
| SCHEMBL16935193 | 0.78 | ALDH1A1 (0.47) | EZH2EZH1KDM4EALDH1A1HPGD | |
| SCHEMBL29473806 | 0.76 | EZH2 (0.43) | EZH2ROCK2ROCK1EZH1 | |
| SCHEMBL28598243 | 0.75 | CCR5 (0.50) | EZH2ALDH1A1HPGD | |
| SCHEMBL28605072 | 0.75 | EZH2 (0.46) | EZH2EZH1KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113045494-B | Pyridone derivative and application thereof in preparation of drugs for preventing and/or treating tuberculosis caused by mycobacterium tuberculosis | 四川大学华西医院 | 2022-04-26 | — | — | CN | disclosed |
| CN-113045494-A | Pyridone derivative and application thereof in preparation of drugs for preventing and/or treating tuberculosis caused by mycobacterium tuberculosis | 四川大学华西医院 | 2021-06-29 | — | — | CN | disclosed |