Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.44 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.44 |
| ▸ | EZH2 | Q15910 | 4/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | EZH1 | Q92800 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29473822 | 1.00 | SMN1; SMN2 (0.52) | SMN1; SMN2TDP1ALDH1A1MEN1KMT2A | |
| SCHEMBL28601010 | 0.88 | EZH2 (0.45) | ALDH1A1EZH2EZH1 | |
| SCHEMBL29473806 | 0.85 | EZH2 (0.43) | EZH2EZH1 | |
| SCHEMBL28598243 | 0.85 | CCR5 (0.50) | SMN1; SMN2ALDH1A1MEN1KMT2AEZH2 | |
| SCHEMBL28609838 | 0.84 | EZH2 (0.48) | ALDH1A1EZH2EZH1KDM4EHSD17B10 | |
| SCHEMBL29473820 | 0.83 | ROCK2 (0.49) | EZH2 | |
| SCHEMBL28602816 | 0.82 | ALDH1A1 (0.49) | SMN1; SMN2ALDH1A1KMT2AEZH2HDAC1 | |
| SCHEMBL28598409 | 0.82 | MMP13 (0.45) | SMN1; SMN2ALDH1A1MEN1KMT2AEZH2 | |
| SCHEMBL28601006 | 0.81 | EPHX2 (0.49) | EZH2NR1H4EZH1 | |
| SCHEMBL28597396 | 0.81 | CCR5 (0.48) | SMN1; SMN2EZH2EZH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113045494-B | Pyridone derivative and application thereof in preparation of drugs for preventing and/or treating tuberculosis caused by mycobacterium tuberculosis | 四川大学华西医院 | 2022-04-26 | — | — | CN | disclosed |
| CN-113045494-A | Pyridone derivative and application thereof in preparation of drugs for preventing and/or treating tuberculosis caused by mycobacterium tuberculosis | 四川大学华西医院 | 2021-06-29 | — | — | CN | disclosed |