Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2857391 | 0.85 | ALDH1A1 (0.48) | MAPTLMNAPKMMAPK14ALDH1A1 | |
| SCHEMBL2854493 | 0.84 | GPR142 (0.56) | MAPTLMNAPKMGPR142MAPK14 | |
| SCHEMBL2850486 | 0.82 | MAPT (0.46) | MAPTLMNAPKMMAPK14MAPK1 | |
| SCHEMBL2857174 | 0.81 | LMNA (0.47) | MAPTLMNAPKMMAPK14ALDH1A1 | |
| SCHEMBL2852439 | 0.81 | MAPT (0.56) | MAPTLMNAPKMMAPK14ALDH1A1 | |
| SCHEMBL2857852 | 0.79 | LMNA (0.45) | MAPTLMNAPKMMAPK14ALDH1A1 | |
| SCHEMBL2854702 | 0.77 | USP2 (0.42) | MAPTLMNAALDH1A1MAPK1MRGPRX1 | |
| SCHEMBL2852672 | 0.76 | MAPT (0.60) | MAPTLMNAPKMMAPK14ALDH1A1 | |
| SCHEMBL2856900 | 0.76 | MAPT (0.47) | MAPTLMNAPKMMAPK14NPSR1 | |
| SCHEMBL2856483 | 0.74 | ALDH1A1 (0.45) | MAPTLMNAALDH1A1MAPK1HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |