SCHEMBL28629285

SCHEMBL28629285

Cc1ccc(C#Cc2ccc(Cl)cc2)cc1

nearest known ligand 0.52

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
GRM5 P41594 4/20 0.52
KCNH2 Q12809 2/20 0.52
ADK P55263 1/20 0.51
CA12 O43570 3/20 0.48
CA2 P00918 3/20 0.48
CA9 Q16790 3/20 0.48
CA1 P00915 2/20 0.48
CES2 O00748 1/20 0.48
CES1 P23141 1/20 0.48
CYP2A6 P11509 2/20 0.46
ALDH1A1 P00352 1/20 0.46
FFAR1 O14842 1/20 0.42
LMNA P02545 2/20 0.42
ACHE P22303 1/20 0.42
TDP1 Q9NUW8 1/20 0.42
DRD2 P14416 1/20 0.41
DRD4 P21917 1/20 0.41
DRD3 P35462 1/20 0.41
ACACB O00763 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20015814 0.86 LMNA (0.57) GRM5KCNH2ADKCYP2A6LMNA
SCHEMBL719360 0.86 LMNA (0.57) GRM5KCNH2ADKCYP2A6LMNA
SCHEMBL4457730 0.86 GRM5 (0.64) GRM5KCNH2CA12CA2CA9
SCHEMBL9445826 0.86 GRM5 (0.64) GRM5KCNH2CA12CA2CA9
Charcoal, Activated SCHEMBL31286310 0.83 KCNH2 (0.54) GRM5KCNH2ADKCYP2A6LMNA
SCHEMBL9715647 0.83 GRM5 (0.61) GRM5KCNH2CA12CA2CA9
SCHEMBL12679 0.83
SCHEMBL28318341 0.83 CES2 (0.62) CA2CA9CA1CES2CES1
SCHEMBL6203955 0.83
Hydrochloric Acid SCHEMBL8996220 0.80

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113443952-B Method for selectively synthesizing cis-olefin and trans-olefin by catalyzing alkyne semi-reduction through iridium with hydrogen supplied by water 南通大学 2022-11-04 CN disclosed
CN-113563150-B Method for selectively synthesizing cis-olefin and trans-olefin by catalyzing alkyne semi-reduction through palladium on hydrogen supplied by water 南通大学 2022-09-02 CN disclosed
CN-113443952-A Method for selectively synthesizing cis-olefin and trans-olefin by catalyzing alkyne semi-reduction through iridium with hydrogen supplied by water 南通大学 2021-09-28 CN disclosed