Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | CCR1 | P32246 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2856385 | 0.89 | CCR1 (0.44) | RAB9ACCR1EPHX2KEAP1NFE2L2 | |
| SCHEMBL2862974 | 0.89 | KEAP1 (0.50) | MAPTNPC1RAB9ANPSR1MEN1 | |
| SCHEMBL2855798 | 0.88 | MAPT (0.45) | MAPTNPSR1CCR1MEN1KMT2A | |
| SCHEMBL2856588 | 0.88 | KEAP1 (0.42) | MAPTCCR1MEN1KMT2AEPHX2 | |
| SCHEMBL2853595 | 0.86 | LMNA (0.44) | MAPTNPC1RAB9AEPHX2KEAP1 | |
| SCHEMBL2869545 | 0.85 | KEAP1 (0.40) | MAPTCCR1EPHX2KEAP1NFE2L2 | |
| SCHEMBL2860990 | 0.85 | KEAP1 (0.43) | MAPTCCR1MEN1KMT2AEPHX2 | |
| SCHEMBL2855716 | 0.84 | KEAP1 (0.46) | MAPTNPC1RAB9AKEAP1NFE2L2 | |
| SCHEMBL2853373 | 0.82 | ACHE (0.47) | MAPTNPC1RAB9ANPSR1ACHE | |
| SCHEMBL2854592 | 0.82 | MEN1 (0.40) | MAPTNPSR1MEN1KMT2AEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |