Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 5/20 | 0.53 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | KLK7 | P49862 | 1/20 | 0.46 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.44 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.44 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.44 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.44 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.44 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11311747 | 0.91 | PREP (0.54) | PREPSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL25590373 | 0.89 | PREP (0.47) | PREPFKBP1ANPSR1PSEN1PSEN2 | |
| SCHEMBL22019554 | 0.83 | FKBP1A (0.48) | PREPFKBP1ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL631581 | 0.82 | FKBP1A (0.58) | PREPFKBP1ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL7326760 | 0.80 | FKBP1A (0.66) | PREPFKBP1AKLK7KLK5CTRB1 | |
| SCHEMBL16272917 | 0.80 | FKBP1A (0.66) | PREPFKBP1AKLK7KLK5CTRB1 | |
| SCHEMBL6848058 | 0.79 | PDK1 (0.53) | PREPFKBP1ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL10518225 | 0.78 | PREP (0.64) | PREPSMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL10518215 | 0.78 | PREP (0.64) | PREPSMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL10370731 | 0.77 | PREP (0.66) | PREPSMN1; SMN2NPC1RAB9ACYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260103454-A1 | MODULATORS OF HEMOGLOBIN | GLOBAL BLOOD THERAPEUTICS INC (US) | 2026-04-16 | — | — | US | disclosed |
| US-20230159507-A1 | MODULATORS OF HEMOGLOBIN | GLOBAL BLOOD THERAPEUTICS, INC. | 2023-05-25 | — | — | US | disclosed |
| US-11548880-B2 | Modulators of hemoglobin | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2023-01-10 | — | — | US | disclosed |
| EP-4046988-A1 | 2-FORMYL-3-HYDROXYPHENYLOXYMETHYL COMPOUNDS CAPABLE OF MODULATING HEMOGLOBIN | Global Blood Therapeutics, Inc. (US) | 2022-08-24 | — | — | EP | disclosed |
| CN-113316568-A | 2-formyl-3-hydroxyphenyloxymethyl compounds capable of modulating hemoglobin | 全球血液疗法股份有限公司 | 2021-08-27 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230159507-A1 | MODULATORS OF HEMOGLOBIN | HBG1, HBG2, HBB | PREP 840/4885FKBP1A 1300/4885SMN1; SMN2 1769/4885 |
| US-20260103454-A1 | MODULATORS OF HEMOGLOBIN | HBZ, HBB, HBG2 | PREP 611/4885FKBP1A 1532/4885SMN1; SMN2 1425/4885 |
| US-11548880-B2 | Modulators of hemoglobin | HBG1, HBG2, HBB | PREP 840/4885FKBP1A 1300/4885SMN1; SMN2 1769/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.