SCHEMBL28678120

SCHEMBL28678120

O=C(O)c1ccc(-c2ccc(C(F)(F)F)c(C(=O)O)c2C(F)(F)F)cc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C8 P10632 1/20 0.49
RXRA P19793 2/20 0.49
RXRB P28702 2/20 0.49
RXRG P48443 2/20 0.49
AKR1C3 P42330 1/20 0.47
AKR1C2 P52895 1/20 0.47
HDAC1 Q13547 1/20 0.43
HDAC6 Q9UBN7 1/20 0.43
ADH5 P11766 1/20 0.42
FOLH1 Q04609 1/20 0.41
SRD5A2 P31213 4/20 0.41
EPHX2 P34913 1/20 0.41
BCL2L1 Q07817 1/20 0.41
BAD Q92934 1/20 0.41
MAP4K4 O95819 1/20 0.40
PDK2 Q15119 1/20 0.39
PPARG P37231 1/20 0.38
RORC P51449 1/20 0.38
KIF11 P52732 1/20 0.38
ANO1 Q5XXA6 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29702020 0.87 ALDH1A1 (0.43) AKR1C3AKR1C2HDAC6FOLH1ANO1
SCHEMBL4229287 0.82 AKR1C3 (0.55) RXRARXRBAKR1C3AKR1C2HDAC1
SCHEMBL2524411 0.79 RXRA (0.50) CYP2C8RXRARXRBRXRGAKR1C3
SCHEMBL4239055 0.78 CYP2C8 (0.59) CYP2C8RXRARXRBRXRGAKR1C3
SCHEMBL4849605 0.77 DAO (0.44) RXRARXRBRXRGSRD5A2ANO1
SCHEMBL23302210 0.77 ADH5 (0.63) CYP2C8RXRARXRBRXRGAKR1C3
SCHEMBL31236747 0.76 RXRA (0.58) CYP2C8RXRARXRBRXRGAKR1C3
Hydrochloric Acid SCHEMBL28670680 0.76 ADH5 (0.61) CYP2C8RXRARXRBRXRGAKR1C3
SCHEMBL29869199 0.73 EPHX2 (0.55) CYP2C8RXRARXRBRXRGAKR1C3
SCHEMBL28636307 0.73 ALDH1A1 (0.45) AKR1C3AKR1C2HDAC6FOLH1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113943290-A Polycyclic aromatic compound and application thereof in electroluminescent device 清华大学 2022-01-18 CN disclosed
CN-113943287-A Polycyclic aromatic compound and application thereof in electroluminescent device 清华大学 2022-01-18 CN disclosed