Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCL8 | P10145 | 2/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 8/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.42 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.42 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31741597 | 0.87 | GABRA1 (0.43) | PTGS1LMNACYP3A4HPGDHIF1A | |
| SCHEMBL8945731 | 0.83 | CXCL8 (0.44) | CXCL8PTGS1LMNACYP3A4HPGD | |
| SCHEMBL4824347 | 0.82 | HTT (0.49) | CXCL8PTGS1LMNACYP3A4HPGD | |
| SCHEMBL214223 | 0.82 | HTT (0.49) | CXCL8PTGS1LMNACYP3A4HPGD | |
| SCHEMBL4825414 | 0.82 | HTT (0.49) | CXCL8PTGS1LMNACYP3A4HPGD | |
| SCHEMBL490576 | 0.81 | PTGS2 (0.47) | CXCL8PTGS1LMNACYP3A4HPGD | |
| SCHEMBL30967948 | 0.80 | PTGS2 (0.44) | CXCL8PTGS1LMNACYP3A4HPGD | |
| SCHEMBL30997987 | 0.80 | CXCL8 (0.49) | CXCL8PTGS1LMNACYP3A4HPGD | |
| SCHEMBL29237654 | 0.80 | PTGS2 (0.44) | CXCL8PTGS1LMNACYP3A4HPGD | |
| SCHEMBL3290293 | 0.79 | HPGD (0.50) | CXCL8PTGS1LMNACYP3A4HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8673920-B2 | Inhibitors of the renal outer medullary potassium channel | MERCK SHARP & DOHME CORP. (US) | 2014-03-18 | — | — | US | disclosed |
| EP-2427444-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | Merck Sharp & Dohme Corp. (US) | 2012-03-14 | — | — | EP | disclosed |
| US-20100286123-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME LLC | 2010-11-11 | — | — | US | disclosed |
| CN-100554254-C | Be used for synthesizing taxone pharmaceutical side-chain De oxazolidine compound and preparation method | BEIJING NUORUI MEDICAL TECHNOL (CN) | 2009-10-28 | — | — | CN | disclosed |
| CN-101033216-A | Oxazolidine compound for synthesizing taxone pharmaceutical side-chain and preparation method thereof | BEIJING NUORUI MEDICAL TECHNOL (CN) | 2007-09-12 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100286123-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | KCNJ11, KCNJ1, KCNJ2 | CXCL8 3003/4885PTGS1 1481/4885LMNA 1188/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.