Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | LTA4H | P09960 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | CA4 | P22748 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4600384 | 0.77 | TSHR (0.36) | TSHRLTA4HHDAC1HDAC2ALDH1A1 | |
| Lithium Ion SCHEMBL28588806 | 0.75 | LTA4H (0.43) | TSHRLTA4HALDH1A1CA4 | |
| Potassium Ion SCHEMBL187986 | 0.75 | LTA4H (0.43) | TSHRLTA4HALDH1A1CA4 | |
| SCHEMBL4980059 | 0.73 | CA1 (0.36) | TSHRLTA4HHDAC1HDAC2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL28630387 | 0.73 | LTA4H (0.41) | TSHRLTA4HALDH1A1CA4 | |
| SCHEMBL29151345 | 0.72 | CA4 (0.34) | TSHRLTA4HHDAC1HDAC2ALDH1A1 | |
| SCHEMBL414391 | 0.71 | LTA4H (0.43) | TSHRLTA4HALDH1A1CA4 | |
| Lithium Ion SCHEMBL188290 | 0.71 | LTA4H (0.43) | TSHRLTA4HALDH1A1CA4 | |
| SCHEMBL187417 | 0.71 | LTA4H (0.43) | TSHRLTA4HALDH1A1CA4 | |
| SCHEMBL188076 | 0.71 | LTA4H (0.43) | TSHRLTA4HALDH1A1CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114002297-A | Dopamine ion carrier, dopamine sensitive membrane containing same, dopamine probe and preparation method | 何成 | 2022-02-01 | — | — | CN | disclosed |