Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.55 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.55 |
| ▸ | DHFR | P00374 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.49 |
| ▸ | PPARG | P37231 | 2/20 | 0.48 |
| ▸ | PPARA | Q07869 | 2/20 | 0.48 |
| ▸ | PPARD | Q03181 | 1/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | PRKCG | P05129 | 1/20 | 0.48 |
| ▸ | LYN | P07948 | 1/20 | 0.48 |
| ▸ | PRKACA | P17612 | 1/20 | 0.48 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.48 |
| ▸ | AKT1 | P31749 | 1/20 | 0.48 |
| ▸ | FLT3 | P36888 | 1/20 | 0.48 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.48 |
| ▸ | CLK2 | P49760 | 1/20 | 0.48 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.48 |
| ▸ | PRKX | P51817 | 1/20 | 0.48 |
| ▸ | NEK4 | P51957 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8347743 | 0.85 | RAB9A (0.54) | HDAC1MAPTCYP2D6HTTRAB9A | |
| SCHEMBL8347988 | 0.81 | PTPN11 (0.59) | PTPN11HDAC1MAOBMAPTHTT | |
| SCHEMBL3898944 | 0.81 | PTPN1 (0.52) | PTPN1PTPN11DHFRHDAC1PPARG | |
| SCHEMBL2804015 | 0.79 | RAB9A (0.41) | MAPTRAB9ANPC1 | |
| SCHEMBL13996529 | 0.77 | DYRK1A (0.60) | PTPN1PTPN11DHFRPPARGPPARA | |
| SCHEMBL2858603 | 0.77 | RAB9A (0.40) | PPARGPPARAPPARDMAPTHTT | |
| SCHEMBL14160762 | 0.75 | APP (0.36) | PPARGPPARAPPARDMAPTHTT | |
| SCHEMBL544909 | 0.75 | ESR1 (0.39) | MAPTRAB9ANPC1 | |
| SCHEMBL2861550 | 0.75 | ILK (0.58) | CYP2D6HTT | |
| SCHEMBL5906677 | 0.75 | APP (0.61) | MAPTRAB9ANPC1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7723366-B2 | Azole compounds as malonyl-CoA decarboxylase inhibitors for treating metabolic diseases | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2010-05-25 | — | — | US | disclosed |
| EP-1379243-B1 | METHODS FOR TREATING METABOLIC DISEASES USING MALONYL-COA DECARBOXYLASE INHIBITORS | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2009-09-09 | — | — | EP | disclosed |
| US-20040082564-A1 | Methods for treating metabolic diseases using malonyl-coa decarboxylase inhibitors | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2004-04-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040082564-A1 | Methods for treating metabolic diseases using malonyl-coa decarboxylase inhibitors | ME1, ME3, ME2 | PTPN1 2501/4885PTPN11 3660/4885DHFR 170/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.