Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRPF1 | P55201 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 3/20 | 0.40 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29469356 | 1.00 | BRPF1 (0.45) | BRPF1HPGDALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL9593575 | 0.86 | CA2 (0.48) | BRPF1HPGDALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL10745201 | 0.79 | LMNA (0.60) | HPGDALDH1A1HTTSMN1; SMN2KDM4E | |
| SCHEMBL28692220 | 0.73 | BRPF1 (0.43) | BRPF1HPGDALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL12060147 | 0.73 | MET (0.45) | BRPF1HPGDALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL6742234 | 0.73 | PTGS2 (0.42) | HPGDALDH1A1SMN1; SMN2LMNACA12 | |
| SCHEMBL28702492 | 0.72 | CYP2A6 (0.37) | ALDH1A1SMN1; SMN2KDM4ELMNACA12 | |
| SCHEMBL29433439 | 0.72 | CYP2A6 (0.37) | ALDH1A1SMN1; SMN2KDM4ELMNACA12 | |
| SCHEMBL10747755 | 0.71 | ALDH1A1 (0.36) | HPGDALDH1A1KDM4ELMNACA12 | |
| SCHEMBL30186176 | 0.71 | CA1 (0.67) | BRPF1HPGDALDH1A1HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114075189-A | Five-membered heterocyclic acene ring compound and preparation method and medical application thereof | 南京柯菲平盛辉制药有限公司 | 2022-02-22 | — | — | CN | disclosed |