SCHEMBL28700196

SCHEMBL28700196

O=C1C=C(Oc2ccccc2)C(=O)C(Oc2ccccc2)=C1Oc1ccccc1

nearest known ligand 0.65

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
GAPDH P04406 4/20 0.65
CES2 O00748 7/20 0.59
CES1 P23141 7/20 0.59
HKDC1 Q2TB90 2/20 0.43
NSD2 O96028 1/20 0.43
HSP90AA1 P07900 1/20 0.43
TLR9 Q9NR96 1/20 0.43
LTA4H P09960 1/20 0.42
TSHR P16473 1/20 0.42
P4HB P07237 1/20 0.39
HTT P42858 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
MAOA P21397 2/20 0.38
MAOB P27338 2/20 0.38
ALOX5 P09917 1/20 0.38
GSTP1 P09211 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13879154 0.81 CES2 (0.64) GAPDHCES2CES1HKDC1NSD2
SCHEMBL4468407 0.78 GAPDH (1.00) GAPDHCES2CES1HKDC1NSD2
SCHEMBL8720193 0.78 LTA4H (0.61) GAPDHCES2CES1HKDC1NSD2
SCHEMBL6432470 0.73 LTA4H (0.55) GAPDHCES2CES1HKDC1NSD2
SCHEMBL17594909 0.72 GAPDH (0.89) GAPDHCES2CES1NSD2P4HB
SCHEMBL1802680 0.72 NSD2 (0.73) GAPDHCES2CES1HKDC1NSD2
SCHEMBL28721937 0.71 GAPDH (0.68) GAPDHCES2CES1HKDC1NSD2
SCHEMBL3363900 0.69 MAOA (0.55) GAPDHCES2CES1LTA4HTSHR
Anthraquinone SCHEMBL3750915 0.69 NSD2 (0.58) GAPDHCES2CES1HKDC1NSD2
SCHEMBL6256773 0.66 LTA4H (0.50) GAPDHCES2CES1HKDC1NSD2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114007649-A Targeted synergistic cancer immunotherapy 布里格姆及妇女医院股份有限公司 2022-02-01 CN claimed
CN-114007649-A Targeted synergistic cancer immunotherapy 布里格姆及妇女医院股份有限公司 2022-02-01 CN disclosed