Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.41 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL28368169 | 0.86 | LMNA (0.52) | TAAR1ALDH1A1KDM4ELMNABLM | |
| SCHEMBL11300491 | 0.80 | TAAR1 (0.79) | TAAR1KDM4EAOC3 | |
| Maleic Acid SCHEMBL28690962 | 0.78 | TAAR1 (0.50) | TAAR1ALDH1A1KDM4ELMNABLM | |
| Pyridine SCHEMBL28404244 | 0.75 | SIGMAR1 (0.50) | TAAR1ALDH1A1KDM4EAOC3L3MBTL1 | |
| SCHEMBL9152202 | 0.73 | TAAR1 (0.55) | TAAR1KDM4EAOC3RAB9ANPC1 | |
| SCHEMBL3056908 | 0.71 | TAAR1 (1.00) | TAAR1AOC3 | |
| SCHEMBL14559621 | 0.70 | CNR1 (0.59) | TAAR1ALDH1A1RAB9AMEN1NPC1 | |
| Hydrochloric Acid SCHEMBL8507687 | 0.70 | TAAR1 (0.96) | TAAR1AOC3CYP3A4 | |
| SCHEMBL27813504 | 0.69 | ALDH1A1 (0.61) | TAAR1ALDH1A1HCAR2MEN1KMT2A | |
| SCHEMBL18762842 | 0.69 | SIGMAR1 (0.61) | TAAR1AOC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114062530-A | Determination and analysis method for isomer impurities in crude chlorpheniramine maleate product | 浙江美诺华药物化学有限公司 | 2022-02-18 | — | — | CN | disclosed |