Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 1/20 | 0.46 |
| ▸ | HTR6 | P50406 | 8/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | CTSG | P08311 | 1/20 | 0.41 |
| ▸ | CMA1 | P23946 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | PKLR | P30613 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4424525 | 0.86 | MET (0.44) | METHTR6CYP3A4HDAC1NFE2L2 | |
| SCHEMBL1156596 | 0.85 | PKM (0.45) | HTR6HDAC1PKMPKLRHDAC3 | |
| SCHEMBL1156351 | 0.83 | MET (0.43) | METHTR6CYP3A4HDAC1HDAC3 | |
| SCHEMBL28715560 | 0.82 | HTR6 (0.49) | METHTR6CYP3A4NFE2L2KEAP1 | |
| SCHEMBL1156134 | 0.81 | PARL (0.42) | HTR6CYP3A4HDAC1HDAC3HDAC2 | |
| SCHEMBL28700638 | 0.80 | PKM (0.40) | HTR6CYP3A4HDAC1PKMHDAC3 | |
| SCHEMBL29202309 | 0.78 | HTR6 (0.37) | HTR6CYP3A4LMNAMAPK1HTR2A | |
| SCHEMBL31187441 | 0.77 | LMNA (0.35) | HTR6PKMLMNAPOLBL3MBTL1 | |
| SCHEMBL4424529 | 0.77 | HTR6 (0.44) | METHTR6CYP3A4PKMPKLR | |
| SCHEMBL29262662 | 0.76 | LMNA (0.50) | METLMNAMAPK1POLBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114105962-B | Sulfonamide structure-containing compound, preparation method and application thereof, pharmaceutical composition and application thereof | 南京烁慧医药科技有限公司 | 2024-11-05 | — | — | CN | disclosed |
| CN-114105962-A | Compound containing sulfonamide structure, preparation method and application thereof, and pharmaceutical composition and application thereof | 南京烁慧医药科技有限公司 | 2022-03-01 | — | — | CN | disclosed |