Sugi Predict

Sugi Predict / Compounds / SCHEMBL287541

SCHEMBL287541

SCHEMBL287541

N[C@H](CC1CCC1)C(=O)O

nearest known ligand 0.50

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ SLC1A3 P43003 2/20 0.47
▸ SLC1A2 P43004 2/20 0.47
▸ SLC1A1 P43005 2/20 0.47
▸ GRIN2D O15399 5/20 0.46
▸ GRIN3B O60391 5/20 0.46
▸ GRIN1 Q05586 5/20 0.46
▸ GRIN2A Q12879 5/20 0.46
▸ GRIN2B Q13224 5/20 0.46
▸ GRIN2C Q14957 5/20 0.46
▸ GRIN3A Q8TCU5 5/20 0.46
▸ ANPEP P15144 1/20 0.43
▸ ALOX5 P09917 1/20 0.42
▸ GRIK1 P39086 1/20 0.42
▸ GRIK2 Q13002 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7937756 1.00 SLC1A3 (0.47) SLC1A3SLC1A2SLC1A1GRIN2DGRIN3B
SCHEMBL287542 1.00 SLC1A3 (0.47) SLC1A3SLC1A2SLC1A1GRIN2DGRIN3B
SCHEMBL841679 1.00 SLC1A3 (0.47) SLC1A3SLC1A2SLC1A1GRIN2DGRIN3B
Hydrochloric Acid SCHEMBL31323920 0.98 SLC1A3 (0.46) SLC1A3SLC1A2SLC1A1GRIN2DGRIN3B
Hydrochloric Acid SCHEMBL6822770 0.98 SLC1A3 (0.46) SLC1A3SLC1A2SLC1A1GRIN2DGRIN3B
Hydrochloric Acid SCHEMBL6822769 0.98 SLC1A3 (0.46) SLC1A3SLC1A2SLC1A1GRIN2DGRIN3B
SCHEMBL437748 0.95 GRIN2D (0.50) SLC1A3SLC1A2SLC1A1GRIN2DGRIN3B
SCHEMBL288282 0.95 GRIN2D (0.50) SLC1A3SLC1A2SLC1A1GRIN2DGRIN3B
SCHEMBL7935130 0.95 GRIN2D (0.50) SLC1A3SLC1A2SLC1A1GRIN2DGRIN3B
SCHEMBL288281 0.95 GRIN2D (0.50) SLC1A3SLC1A2SLC1A1GRIN2DGRIN3B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9695191-B2 Conformationally constrained, fully synthetic macrocyclic compounds POLYPHOR AG (CH) 2017-07-04 — — US claimed
EP-2462147-B1 CONFORMATIONALLY CONSTRAINED, FULLY SYNTHETIC MACROCYCLIC COMPOUNDS POLYPHOR AG (CH) 2014-11-12 — — EP claimed
US-20120202821-A1 CONFORMATIONALLY CONSTRAINED, FULLY SYNTHETIC MACROCYCLIC COMPOUNDS POLYPHOR AG (CH) 2012-08-09 — — US claimed
US-20250243196-A1 CITRON KINASE INHIBITORS THE CLEVELAND CLINIC FOUNDATION 2025-07-31 — — US disclosed
CN-118791553-A Peptide-like compound combined with WDR5 protein WIN pocket and application thereof 浙江大学 2024-10-18 — — CN disclosed
WO-2023196429-A1 MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR VERTEX PHARMACEUTICALS INCORPORATED (US) 2023-10-12 — — WO disclosed
CN-116601158-A Modulators of cystic fibrosis transmembrane conductance regulator 弗特克斯药品有限公司 2023-08-15 — — CN disclosed
US-11674136-B2 DNA-templated macrocycle library PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2023-06-13 — — US disclosed
US-11674136-B2 DNA-templated macrocycle library PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2023-06-13 — — US disclosed
US-11674136-B2 DNA-templated macrocycle library PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2023-06-13 — — US disclosed
US-20230117680-A1 CYCLOPHILIN D INHIBITORS AND USES THEREOF THE BROAD INSTITUTE, INC. (US) 2023-04-20 — — US disclosed
WO-2010084428-A1 SUBSTITUTED PYRAZINONE AMIDES PFIZER INC. (US) 2010-07-29 — — WO disclosed
WO-2010084428-A1 SUBSTITUTED PYRAZINONE AMIDES PFIZER INC. (US) 2010-07-29 — — WO disclosed
US-20100184777-A1 Substituted Pyrazinone Amides PFIZER INC 2010-07-22 — — US disclosed
US-20100184777-A1 Substituted Pyrazinone Amides PFIZER INC 2010-07-22 — — US disclosed
US-20100184777-A1 Substituted Pyrazinone Amides PFIZER INC 2010-07-22 — — US disclosed
EP-0922054-B1 ANTICOAGULANT PEPTIDYL-ARGININE ALDEHYDE DERIVATIVES GYOGYSZERKUTATO INTEZET (HU) 2002-08-14 — — EP disclosed
US-6235707-B1 Anticoagulant peptidyl-arginine aldehyde derivatives GYOGYSZERKUTATO INTEZET KFT. (HU) 2001-05-22 — — US disclosed
EP-0922054-A1 ANTICOAGULANT PEPTIDYL-ARGININE ALDEHYDE DERIVATIVES GYOGYSZERKUTATO INTEZET KFT. (HU) 1999-06-16 — — EP disclosed
WO-1997046576-A1 ANTICOAGULANT PEPTIDYL-ARGININE ALDEHYDE DERIVATIVES Gyógyszerkutató Intézet Kft. (HU) 1997-12-11 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120202821-A1 CONFORMATIONALLY CONSTRAINED, FULLY SYNTHETIC MACROCYCLIC COMPOUNDS HTR2B, MC1R, HTR1A SLC1A3 2430/4885SLC1A2 1491/4885SLC1A1 2314/4885
US-20100184777-A1 Substituted Pyrazinone Amides GCK, GCKR, PDK2 SLC1A3 2216/4885SLC1A2 2141/4885SLC1A1 1922/4885
US-11674136-B2 DNA-templated macrocycle library IDE, IAPP, POLRMT SLC1A3 2362/4885SLC1A2 2131/4885SLC1A1 2357/4885
US-20250243196-A1 CITRON KINASE INHIBITORS CHEK2, CILK1, DCK SLC1A3 3832/4885SLC1A2 3965/4885SLC1A1 3795/4885
US-20230117680-A1 CYCLOPHILIN D INHIBITORS AND USES THEREOF PPID, PPIF, PPIL1 SLC1A3 3251/4885SLC1A2 3284/4885SLC1A1 3088/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.