Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM1 | Q13255 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 2/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27800576 | 0.81 | MEN1 (0.36) | GRM1CYP3A4TSHR | |
| SCHEMBL28749904 | 0.77 | CYP3A4 (0.50) | CYP3A4TSHRPIK3CAESR1KCNH2 | |
| SCHEMBL28765675 | 0.76 | GRM1 (0.33) | GRM1CYP3A4TSHRPIK3CA | |
| SCHEMBL27705286 | 0.73 | TDP1 (0.43) | CYP3A4TSHRKCNH2 | |
| SCHEMBL1801222 | 0.70 | CYP3A4 (0.48) | CYP3A4TSHRPIK3CAESR1ESR2 | |
| SCHEMBL27304888 | 0.68 | ALDH1A1 (0.40) | CYP3A4TSHR | |
| SCHEMBL27686304 | 0.68 | MAPK1 (0.35) | CYP3A4TSHRESR1ESR2 | |
| SCHEMBL27691525 | 0.68 | PTGS1 (0.33) | CYP3A4TSHR | |
| SCHEMBL27691694 | 0.68 | ADRB2 (0.39) | — | |
| SCHEMBL27831460 | 0.68 | PTGS1 (0.33) | GRM1CYP3A4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101955470-B | Potentiators of glutamate receptors | LILLY CO ELI | 2012-06-13 | — | — | CN | disclosed |
| CN-101955470-A | Glutamate receptor potentiators | LILLY CO ELI | 2011-01-26 | — | — | CN | disclosed |
| CN-101061106-B | Glutamate receptor potentiators | LILLY CO ELI | 2010-09-29 | — | — | CN | disclosed |
| CN-101061106-A | Glutamate receptor potentiators | LILLY CO ELI (US) | 2007-10-24 | — | — | CN | disclosed |