Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 5/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL288833 | 0.81 | DHODH (0.47) | ALDH1A1NOTUMDRD2DRD4 | |
| SCHEMBL8527554 | 0.73 | NOTUM (0.62) | ALDH1A1MAPTSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL853846 | 0.71 | PDK1 (0.50) | ALDH1A1MAPTSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL288802 | 0.71 | SLC22A12 (0.59) | ALDH1A1NPC1NOTUMLMNA | |
| SCHEMBL3971068 | 0.71 | NOTUM (0.73) | MAPTSMN1; SMN2RAB9ANPC1NOTUM | |
| SCHEMBL7981548 | 0.71 | NOTUM (0.73) | ALDH1A1MAPTSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL15690093 | 0.71 | NOTUM (0.49) | ALDH1A1MAPTSMN1; SMN2NOTUMLMNA | |
| SCHEMBL31647180 | 0.70 | NOTUM (0.56) | ALDH1A1MAPTSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL8528919 | 0.69 | NOTUM (0.67) | ALDH1A1MAPTSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL28693772 | 0.69 | NOTUM (0.54) | ALDH1A1MAPTSMN1; SMN2RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427450-A1 | GPR 119 MODULATORS | Pfizer Inc. (US) | 2012-03-14 | — | — | EP | disclosed |
| EP-2427448-A1 | Gpr 119 modulators | Pfizer Inc. (US) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010128425-A1 | GPR 119 MODULATORS | PFIZER INC. (US) | 2010-11-11 | — | — | WO | disclosed |
| WO-2010128414-A1 | GPR 119 MODULATORS | PFIZER INC. (US) | 2010-11-11 | — | — | WO | disclosed |
| US-20100285145-A1 | GPR 119 MODULATORS | PFIZER INC | 2010-11-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100285145-A1 | GPR 119 MODULATORS | GPR119, GPR65, GPR39 | ALDH1A1 1516/4885MAPT 3590/4885SMN1; SMN2 1916/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.