Icosapent

Icosapent

SCHEMBL2877007

CCC=CC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 10/20 1.00
PPARG P37231 8/20 1.00
F7 P08709 7/20 1.00
F3 P13726 7/20 1.00
CYP19A1 P11511 6/20 1.00
PPARD Q03181 6/20 1.00
PPARA Q07869 6/20 1.00
PTGS1 P23219 5/20 1.00
OXER1 Q8TDS5 4/20 1.00
KMT2A Q03164 3/20 1.00
RXRA P19793 2/20 1.00
ADORA3 P0DMS8 1/20 1.00
FFAR1 O14842 5/20 0.85
MAPT P10636 4/20 0.85
L3MBTL1 Q9Y468 3/20 0.85
KDM4E B2RXH2 3/20 0.85
LMNA P02545 3/20 0.85
CYP3A4 P08684 3/20 0.85
HPGD P15428 3/20 0.85
ALOX15 P16050 3/20 0.85

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Icosapent SCHEMBL18185487 1.00 ALDH1A1 (1.00) ALDH1A1PPARGF7F3CYP19A1
Icosapent SCHEMBL1648318 1.00 ALDH1A1 (1.00) ALDH1A1PPARGF7F3CYP19A1
SCHEMBL12828369 1.00 ALDH1A1 (1.00) ALDH1A1PPARGF7F3CYP19A1
Icosapent SCHEMBL1648015 1.00 ALDH1A1 (1.00) ALDH1A1PPARGF7F3CYP19A1
Icosapent SCHEMBL2877002 1.00 ALDH1A1 (1.00) ALDH1A1PPARGF7F3CYP19A1
SCHEMBL23417014 1.00 ALDH1A1 (1.00) ALDH1A1PPARGF7F3CYP19A1
Icosapent SCHEMBL18185494 1.00 ALDH1A1 (1.00) ALDH1A1PPARGF7F3CYP19A1
Icosapent SCHEMBL18274961 1.00 ALDH1A1 (1.00) ALDH1A1PPARGF7F3CYP19A1
Icosapent SCHEMBL18185412 1.00 ALDH1A1 (1.00) ALDH1A1PPARGF7F3CYP19A1
Icosapent SCHEMBL18185423 1.00 ALDH1A1 (1.00) ALDH1A1PPARGF7F3CYP19A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250122219-A1 BRIDGED TRICYCLIC CARBAMOYLPYRIDONE COMPOUNDS AND USES THEREOF GILEAD SCIENCES, INC. 2025-04-17 US disclosed
US-20100317639-A1 Medicament Based On a Monoester of Steroids With Long Chain Fatty Acids PETRONI ANNA 2010-12-16 US disclosed
EP-1962856-B1 MEDICAMENT BASED ON A MONOESTER OF STEROIDS WITH LONG CHAIN FATTY ACIDS PETRONI ANNA (IT) 2010-10-20 EP disclosed
US-20060147706-A1 Sizing composition for glass staple fibres, method using said composition and resulting products SAINT-GOBAIN VETROTEX FRANCE S.A. (FR) 2006-07-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100317639-A1 Medicament Based On a Monoester of Steroids With Long Chain Fatty Acids ACAT1, ACAT2, HSD17B12 ALDH1A1 278/4885PPARG 96/4885F7 4304/4885
US-20250122219-A1 BRIDGED TRICYCLIC CARBAMOYLPYRIDONE COMPOUNDS AND USES THEREOF SDHA, SDHB, DPYD ALDH1A1 684/4885PPARG 1889/4885F7 2048/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.