Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2877172 | 1.00 | GAA (0.43) | GAAMAPTLMNASIRT1NPC1 | |
| SCHEMBL2877169 | 1.00 | GAA (0.43) | GAAMAPTLMNASIRT1NPC1 | |
| Potassium SCHEMBL8627342 | 0.99 | GAA (0.43) | GAAMAPTLMNASIRT1NPC1 | |
| SCHEMBL8627333 | 0.99 | GAA (0.43) | GAAMAPTLMNASIRT1NPC1 | |
| Potassium Ion SCHEMBL8627336 | 0.92 | HDAC3 (0.39) | GAAMAPTLMNASIRT1NPC1 | |
| SCHEMBL8575344 | 0.87 | HDAC3 (0.39) | GAAMAPTLMNASIRT1NPC1 | |
| SCHEMBL9364230 | 0.86 | SIRT1 (0.38) | GAALMNASIRT1NPC1RAB9A | |
| SCHEMBL8441610 | 0.86 | SIRT1 (0.38) | GAALMNASIRT1NPC1RAB9A | |
| SCHEMBL27317178 | 0.85 | MAPT (0.45) | GAAMAPTLMNANPC1RAB9A | |
| SCHEMBL20887071 | 0.85 | LMNA (0.46) | GAAMAPTLMNASIRT1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100292185-A1 | BETA-LACTAMASE INHIBITORS | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD (BM) | 2010-11-18 | — | — | US | disclosed |
| US-20040260084-A1 | Novel c-3 s/o-and s/n formaldehe acetal derivatives of cephalosporins and their use as antibotics | PFAENDLER HANS R (DE) | 2004-12-23 | — | — | US | disclosed |
| EP-1444237-A1 | NOVEL C-3 S/O- AND S/N FORMALDEHE ACETAL DERIVATIVES OF CEPHALO SPORINS AND THEIR USE AS ANTIBIOTICS | Pfaendler, Hans Rudolf (DE) | 2004-08-11 | — | — | EP | disclosed |
| WO-2003042219-A1 | NOVEL C-3 S/O- AND S/N FORMALDEHE ACETAL DERIVATIVES OF CEPHALO SPORINS AND THEIR USE AS ANTIBIOTICS | PFAENDLER HANS RUDOLF (DE) | 2003-05-22 | — | — | WO | disclosed |
| EP-1077981-B1 | NOVEL CEPHALOSPORIN COMPOUNDS, PROCESSES FOR PREPARATION THEREOF AND ANTIMICROBIAL COMPOSITIONS CONTAINING THE SAME | LG CHEMICAL LTD (KR) | 2002-08-07 | — | — | EP | disclosed |
| EP-0594263-B1 | INTERMEDIATES FOR THE PREPARATION OF THIOALKYLTHIO CEPHALOSPORIN DERIVATIVES | SHIONOGI & CO (JP) | 1999-06-09 | — | — | EP | disclosed |
| CN-1034504-C | Thioalkylthio cephalosporin derivatives | SHIONOGI & CO (JP) | 1997-04-09 | — | — | CN | disclosed |
| EP-0409164-B1 | Phenacylpyridiniothiocephalosporins | SHIONOGI & CO (JP) | 1996-06-05 | — | — | EP | disclosed |
| US-5352792-A | Bactericides | SHIONOGI & CO., LTD. (JP) | 1994-10-04 | — | — | US | disclosed |
| EP-0467647-B1 | Thioalkylthio cephalosporin derivatives | SHIONOGI & CO (JP) | 1994-08-17 | — | — | EP | disclosed |
| EP-0594263-A1 | Thioalkylthio cephalosporin derivatives and intermediates | SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD. (JP) | 1994-04-27 | — | — | EP | disclosed |
| US-5214037-A | Antibiotic, bactericide | SHIONOGI & CO., LTD. (JP) | 1993-05-25 | — | — | US | disclosed |
| US-5134138-A | ANTIBIOTICS | SHIONOGI & CO., LTD. (JP) | 1992-07-28 | — | — | US | disclosed |
| EP-0467647-A2 | Thioalkylthio cephalosporin derivatives | SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD. (JP) | 1992-01-22 | — | — | EP | disclosed |
| EP-0409164-A2 | Phenacylpyridiniothiocephalosporins | SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD. (JP) | 1991-01-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040260084-A1 | Novel c-3 s/o-and s/n formaldehe acetal derivatives of cephalosporins and their use as antibotics | CBR3, CBR1, SULT1E1 | GAA 3224/4885MAPT 4819/4885LMNA 3654/4885 |
| US-20100292185-A1 | BETA-LACTAMASE INHIBITORS | GANAB, BPGM, BLVRB | GAA 4/4885MAPT 3009/4885LMNA 1592/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.