Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 4/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.39 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2877169 | 0.92 | GAA (0.43) | HDAC3HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL2877172 | 0.92 | GAA (0.43) | HDAC3HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL2877170 | 0.92 | GAA (0.43) | HDAC3HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL8627333 | 0.91 | GAA (0.43) | HDAC3HDAC1HDAC2HDAC10HDAC8 | |
| Potassium SCHEMBL8627342 | 0.91 | GAA (0.43) | HDAC3HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL8575344 | 0.87 | HDAC3 (0.39) | HDAC3HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL8441610 | 0.84 | SIRT1 (0.38) | HDAC3HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL9364230 | 0.84 | SIRT1 (0.38) | HDAC3HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL9060569 | 0.82 | LMNA (0.50) | HDAC3HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL9060577 | 0.82 | LMNA (0.50) | HDAC3HDAC1HDAC2HDAC10HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-10168071-A | — | — | None | — | — | JP | disclosed |
| JP-H10168071-A | 2-AMINOTHIAZOLEACETIC ACID SALT DERIVATIVE AND ITS PRODUCTION | TOKUYAMA CORP | 1998-06-23 | — | — | JP | disclosed |