Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 7/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4123928 | 0.87 | PDK2 (0.32) | PDK2 | |
| SCHEMBL12692197 | 0.87 | PDK2 (0.32) | PDK2 | |
| SCHEMBL4120103 | 0.84 | CHRM2 (0.36) | PDK2KMT2ACYP2C19NPSR1CYP2C9 | |
| SCHEMBL28781250 | 0.83 | PDK2 (0.32) | PDK2 | |
| SCHEMBL3977069 | 0.83 | PDK2 (0.35) | PDK2CYP2C19CYP1A2 | |
| SCHEMBL3978361 | 0.81 | ALDH1A1 (0.44) | PDK2CYP2C19ALDH1A1TSHRNPSR1 | |
| SCHEMBL24614623 | 0.79 | TSHR (0.37) | PDK2CYP2C19ALDH1A1TSHR | |
| SCHEMBL13649405 | 0.79 | PDK2 (0.32) | PDK2 | |
| SCHEMBL4108492 | 0.78 | PDK2 (0.36) | PDK2CYP2C19ALDH1A1TSHRNPSR1 | |
| SCHEMBL22703883 | 0.73 | GPR3 (0.36) | PDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057174-B1 | NEW CYCLOPENTADIENYL, INDENYL OR FLUORENYL SUBSTITUTED PHOSPHINE COMPOUNDS AND THEIR USE IN CATALYTIC REACTIONS | EVONIK DEGUSSA GMBH (DE) | 2014-12-17 | — | — | EP | claimed |
| US-8618328-B2 | Cyclopentadienyl, indenyl or fluorenyl substituted phosphine compounds and their use in catalytic reactions | EVONIK DEGUSSA GMBH (DE) | 2013-12-31 | — | — | US | claimed |
| US-20120245348-A1 | New Cyclopentadienyl, Indenyl or Fluorenyl Substituted Phosphine Compounds and their Use in Catalytic Reactions | PLENIO HERBERT (DE) | 2012-09-27 | — | — | US | claimed |
| JP-2010501617-A | — | — | 2010-01-21 | — | — | JP | claimed |
| US-20090253907-A1 | CYCLOPENTADIENYL, INDENYL OR FLUORENYL SUBSTITUTED PHOSPHINE COMPOUNDS AND THEIR USE IN CATALYTIC REACTIONS | EVONIK DEGUSSA GMBH (DE) | 2009-10-08 | — | — | US | claimed |
| EP-2057174-A1 | NEW CYCLOPENTADIENYL, INDENYL OR FLUORENYL SUBSTITUTED PHOSPHINE COMPOUNDS AND THEIR USE IN CATALYTIC REACTIONS | Evonik Degussa GmbH (DE) | 2009-05-13 | — | — | EP | claimed |
| WO-2008025673-A1 | NEW CYCLOPENTADIENYL, INDENYL OR FLUORENYL SUBSTITUTED PHOSPHINE COMPOUNDS AND THEIR USE IN CATALYTIC REACTIONS | EVONIK DEGUSSA GMBH (DE) | 2008-03-06 | — | — | WO | claimed |
| EP-1894938-A1 | New cyclopentadienyl, indenyl or fluorenyl substituted phosphine compounds and their use in catalytic reactions | Evonik Degussa GmbH (DE) | 2008-03-05 | — | — | EP | claimed |
| US-8969624-B2 | Cyclopentadienyl, indenyl or fluorenyl substituted phosphine compounds and their use in catalytic reactions | EVONIK DEGUSSA GMBH (DE) | 2015-03-03 | — | — | US | disclosed |
| US-8969624-B2 | Cyclopentadienyl, indenyl or fluorenyl substituted phosphine compounds and their use in catalytic reactions | EVONIK DEGUSSA GMBH (DE) | 2015-03-03 | — | — | US | disclosed |
| EP-2057174-B1 | NEW CYCLOPENTADIENYL, INDENYL OR FLUORENYL SUBSTITUTED PHOSPHINE COMPOUNDS AND THEIR USE IN CATALYTIC REACTIONS | EVONIK DEGUSSA GMBH (DE) | 2014-12-17 | — | — | EP | disclosed |
| EP-2057174-B1 | NEW CYCLOPENTADIENYL, INDENYL OR FLUORENYL SUBSTITUTED PHOSPHINE COMPOUNDS AND THEIR USE IN CATALYTIC REACTIONS | EVONIK DEGUSSA GMBH (DE) | 2014-12-17 | — | — | EP | disclosed |
| US-20140058101-A1 | New Cyclopentadienyl, Indenyl or Fluorenyl Substituted Phosphine Compounds and Their Use in Catalytic Reactions | EVONIK DEGUSSA GMBH (DE) | 2014-02-27 | — | — | US | disclosed |
| US-20140058101-A1 | New Cyclopentadienyl, Indenyl or Fluorenyl Substituted Phosphine Compounds and Their Use in Catalytic Reactions | EVONIK DEGUSSA GMBH (DE) | 2014-02-27 | — | — | US | disclosed |
| US-20090253907-A1 | CYCLOPENTADIENYL, INDENYL OR FLUORENYL SUBSTITUTED PHOSPHINE COMPOUNDS AND THEIR USE IN CATALYTIC REACTIONS | EVONIK DEGUSSA GMBH (DE) | 2009-10-08 | — | — | US | disclosed |
| US-20090253907-A1 | CYCLOPENTADIENYL, INDENYL OR FLUORENYL SUBSTITUTED PHOSPHINE COMPOUNDS AND THEIR USE IN CATALYTIC REACTIONS | EVONIK DEGUSSA GMBH (DE) | 2009-10-08 | — | — | US | disclosed |
| US-20090253907-A1 | CYCLOPENTADIENYL, INDENYL OR FLUORENYL SUBSTITUTED PHOSPHINE COMPOUNDS AND THEIR USE IN CATALYTIC REACTIONS | EVONIK DEGUSSA GMBH (DE) | 2009-10-08 | — | — | US | disclosed |
| EP-2057174-A1 | NEW CYCLOPENTADIENYL, INDENYL OR FLUORENYL SUBSTITUTED PHOSPHINE COMPOUNDS AND THEIR USE IN CATALYTIC REACTIONS | Evonik Degussa GmbH (DE) | 2009-05-13 | — | — | EP | disclosed |
| WO-2008025673-A1 | NEW CYCLOPENTADIENYL, INDENYL OR FLUORENYL SUBSTITUTED PHOSPHINE COMPOUNDS AND THEIR USE IN CATALYTIC REACTIONS | EVONIK DEGUSSA GMBH (DE) | 2008-03-06 | — | — | WO | disclosed |
| EP-1894938-A1 | New cyclopentadienyl, indenyl or fluorenyl substituted phosphine compounds and their use in catalytic reactions | Evonik Degussa GmbH (DE) | 2008-03-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120245348-A1 | New Cyclopentadienyl, Indenyl or Fluorenyl Substituted Phosphine Compounds and their Use in Catalytic Reactions | PHOSPHO1, PPP4C, INPP5B | PDK2 168/4885KMT2A 2989/4885CYP2C19 559/4885 |
| US-20140058101-A1 | New Cyclopentadienyl, Indenyl or Fluorenyl Substituted Phosphine Compounds and Their Use in Catalytic Reactions | CPS1, CYCS, PFAS | PDK2 1570/4885KMT2A 3776/4885CYP2C19 706/4885 |
| US-20090253907-A1 | CYCLOPENTADIENYL, INDENYL OR FLUORENYL SUBSTITUTED PHOSPHINE COMPOUNDS AND THEIR USE IN CATALYTIC REACTIONS | CPS1, CYCS, RRS1 | PDK2 944/4885KMT2A 3629/4885CYP2C19 528/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.