Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 2/20 | 0.57 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.57 |
| ▸ | TLR2 | O60603 | 1/20 | 0.56 |
| ▸ | ERN1 | O75460 | 1/20 | 0.56 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.56 |
| ▸ | TLR6 | Q9Y2C9 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | TNFSF11 | O14788 | 1/20 | 0.48 |
| ▸ | ESR1 | P03372 | 1/20 | 0.48 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.48 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8766243 | 0.92 | KDM4E (0.55) | KDM4EMAPK1HSD17B10LMNAMAPT | |
| SCHEMBL979737 | 0.84 | KDM4E (0.57) | KDM4EMAPK1HSD17B10LMNAMAPT | |
| SCHEMBL1458762 | 0.83 | HSD17B10 (0.56) | KDM4EMAPK1HSD17B10LMNAMAPT | |
| SCHEMBL15495901 | 0.83 | LMNA (0.52) | KDM4EMAPK1HSD17B10LMNAMAPT | |
| Syringol SCHEMBL156388 | 0.82 | KDM4E (0.80) | KDM4EMAPK1HSD17B10LMNAMAPT | |
| SCHEMBL3373821 | 0.82 | LMNA (0.55) | KDM4EMAPK1HSD17B10LMNAMAPT | |
| SCHEMBL236191 | 0.81 | CA12 (0.59) | KDM4EHSD17B10LMNAMAPTALDH1A1 | |
| SCHEMBL29655351 | 0.81 | CA12 (0.59) | KDM4EHSD17B10LMNAMAPTALDH1A1 | |
| SCHEMBL15496053 | 0.81 | ELANE (0.47) | KDM4EMAPK1HSD17B10LMNAMAPT | |
| Syringol SCHEMBL28128050 | 0.81 | KDM4E (0.70) | KDM4EMAPK1HSD17B10LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8461384-B2 | Preparation of amides from an acid and amine for intermediates in the synthesis of morphinans | MALLINCKRODT LLC (US) | 2013-06-11 | — | — | US | disclosed |
| US-8445682-B2 | Preparation of 3,4-dihydroisoquinolines from an acid and an amine | MALLINCKRODT LLC (US) | 2013-05-21 | — | — | US | disclosed |
| US-8232400-B2 | Preparation of 3,4-dihydroisoquinolines in the synthesis of morphinans | MALLINCKRODT LLC (US) | 2012-07-31 | — | — | US | disclosed |
| EP-2177504-A1 | Preparation of amides from an acid and amine for intermediates in the synthesis of morphinans | Mallinckrodt Inc. (US) | 2010-04-21 | — | — | EP | disclosed |
| US-20100063290-A1 | Preparation of 3,4-Dihydroisoquinolines from an Acid and an Amine | MALLINCKRODT PHARMACEUTICALS IRELAND LIMITED (IE) | 2010-03-11 | — | — | US | disclosed |
| EP-2161253-A2 | Process for the preparation of 3,4-dihydroisoquinolines in the synthesis of morphinans | Mallinckrodt Inc. (US) | 2010-03-10 | — | — | EP | disclosed |
| US-20090247761-A1 | Preparation of 3,4-Dihydroisoquinolines in the Synthesis of Morphinans | MALLINCKRODT INC. (US) | 2009-10-01 | — | — | US | disclosed |
| US-20090247760-A1 | Preparation of Amides from an Acid and Amine for Intermediates in the Synthesis of Morphinans | MALLINCKRODT INC. (US) | 2009-10-01 | — | — | US | disclosed |
| EP-2099745-A2 | PREPARATION OF 3,4-DIHYDROISOQUINOLINES FROM AN ACID AND AN AMINE | Mallinckrodt Inc. (US) | 2009-09-16 | — | — | EP | disclosed |
| WO-2008073390-A2 | PREPARATION OF 3,4-DIHYDROISOQUINOLINES FROM AN ACID AND AN AMINE | MALLINCKRODT INC. (US) | 2008-06-19 | — | — | WO | disclosed |
| EP-1513817-A1 | 1, 2-AZOLE DERIVATIVES WITH HYPOGLYCEMIC AND HYPOLIPIDEMIC ACTIVITY | Takeda Pharmaceutical Company Limited (JP) | 2005-03-16 | — | — | EP | disclosed |
| WO-2003099793-A9 | 1,2-AZOLE DERIVATIVES WITH HYPOGLYCEMIC AND HYPOLIPIDEMIC ACTIVITY | TAKEDA PHARMACEUTICAL (JP) | 2005-02-10 | — | — | WO | disclosed |
| WO-2003099793-A1 | 1,2-AZOLE DERIVATIVES WITH HYPOGLYCEMIC AND HYPOLIPIDEMIC ACTIVITY | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2003-12-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090247761-A1 | Preparation of 3,4-Dihydroisoquinolines in the Synthesis of Morphinans | PNN, CDKL3, ORAI3 | KDM4E 1369/4885MAPK1 2241/4885HSD17B10 3664/4885 |
| US-20100063290-A1 | Preparation of 3,4-Dihydroisoquinolines from an Acid and an Amine | PNN, AOX1, PAM | KDM4E 1791/4885MAPK1 1672/4885HSD17B10 3258/4885 |
| US-20090247760-A1 | Preparation of Amides from an Acid and Amine for Intermediates in the Synthesis of Morphinans | PNN, PAM, NPM1 | KDM4E 1893/4885MAPK1 1810/4885HSD17B10 3789/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.